Selective Recognition of Co-assembled Thrombin Aptamer and Docetaxel on Mesoporous Silica Nanoparticles against Tumor Cell Proliferation

被引：42

作者：

Gao, Liang ^{[1
]}

Cui, Yue ^{[1
]}

He, Qiang ^{[2
]}

Yang, Yang ^{[3
]}

Fei, Jinbo ^{[1
]}

Li, Junbai ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Key Lab Colloid & Interface Sci,Beijing Natl Lab, Beijing 100190, Peoples R China

[2] Harbin Inst Technol, Micro Nano Technol Res Ctr, Harbin 150080, Peoples R China

[3] Natl Ctr Nanoscicence & Technol, Beijing 100190, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2011年 / 17卷 / 47期

关键词：

antitumor agents; aptamers; co-assembly; drug delivery; liposomes; DNA APTAMER; DRUG-DELIVERY;

D O I：

10.1002/chem.201101658

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Delivery plan: Thrombin binding aptamer tethered to lipid-coated mesoporous silica nanoparticles (TBA A 15-lipid-MSN, above arrow) were rationally designed to deliver docetaxel for combined tumor cell suppression. The dual function of the bioconjugates in the extracellular matrix and cytoplasm of HeLa cells was demonstrated. This hybrid system could be extended for combined anticancer treatment when PAR-1 is over-expressed. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：13170 / 13174

页数：5

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