INDIRECT SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF CAPTOPRIL USING CR(VI) AND DIPHENYLCARBAZIDE

被引：3
作者：
Moldovan, Zenovia [1 ]
Badea, Irinel Adriana [1 ]
Bunaciu, Andrei A. [2 ]
Aboul-Enein, Hassan Y. [3 ]
机构：
[1] Univ Bucharest, Fac Chem, Dept Analyt Chem, Bucharest 050663 5, Romania
[2] CROMATEC PLUS SRL, Analyt Res Dept, Bucharest 060114 6, Romania
[3] Natl Res Ctr, Pharmaceut & Drug Ind Res Div, Pharmaceut & Med Chem Dept, Cairo 12311, Egypt
来源：
QUIMICA NOVA | 2012年 / 35卷 / 08期
关键词：
captopril; diphenylcarbazide; spectrophotometric determination; PHARMACEUTICAL FORMULATIONS; OXIDIMETRIC DETERMINATION; PRECOLUMN DERIVATIZATION; DOSAGE FORMS; HUMAN PLASMA; FLOW SYSTEM; CHROMATOGRAPHY; TABLETS; THIOLS; BULK;
D O I：
10.1590/S0100-40422012000800029
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A spectrophotometric method for the indirect determination of captopril (CP) in pharmaceutical formulations is proposed. The proposed procedure is based on the oxidation of captopril by potassium dichromate and the determination excess oxidant on the basis of its reaction with diphenylcarbazide (DPC). Under the optimum conditions, a good linear relationship (r = 0.9997) was obtained in the range of 0.08-3.5 mu g mL(-1). The assay limits of detection and quantitation were 0.024 and 0.08 mu g mL(-1), respectively. The results obtained for captopril determination in pharmaceuticals using the proposed method and those obtained with the US Pharmacopoeia method were in good agreement at the 95% confidence level.
引用
收藏
页码：1668 / 1672
页数：5
相关论文
共 37 条
[1]  
[Anonymous], 1978, SPECTROCHEM ACTA, V33B, P241, DOI 10.1016/0584-8547(78)80044-5
[2]   NEW SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF CAPTOPRIL BULK DRUG AND TABLETS [J].
ASKAL, HF .
TALANTA, 1991, 38 (10) :1155-1158
[3]  
Basavaiah K, 2004, OXID COMMUN, V27, P203
[4]  
Basavaiah K, 2004, OXID COMMUN, V27, P186
[5]  
Basavaiah K, 2003, OXID COMMUN, V26, P432
[6]  
Basavaiah K., 2003, BULG CHEM COMMUN, V35, P48
[7]   THE REACTION OF CHROMATE WITH DIPHENYLCARBAZIDE .1. [J].
BOSE, M .
ANALYTICA CHIMICA ACTA, 1954, 10 (03) :201-208
[8]   Indirect determination of captopril by AAS [J].
El Reis, MA ;
Abou Attia, FM ;
Kenawy, IMM .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2000, 23 (2-3) :249-254
[9]  
el-Brashy A M, 1995, Acta Pharm Hung, V65, P91
[10]   Utilization of oxidation reactions for the spectrophotometric determination of captopril using brominating agents [J].
El-Didamony, Akram M. ;
Erfan, Eman A. H. .
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2010, 75 (03) :1138-1145
1234