The Therapeutic Potential of Mangosteen Pericarp as an Adjunctive Therapy for Bipolar Disorder and Schizophrenia

被引：15

作者：

Ashton, Melanie M. ^{[1
,2
,3
]}

Dean, Olivia M. ^{[1
,2
,4
]}

Walker, Adam J. ^{[1
]}

Bortolasci, Chiara C. ^{[5
]}

Ng, Chee H. ^{[3
]}

Hopwood, Malcolm ^{[6
]}

Harvey, Brian H. ^{[7
]}

Moller, Marisa ^{[7
]}

McGrath, John J. ^{[8
,9
,10
]}

Marx, Wolfgang ^{[1
]}

Turner, Alyna ^{[1
,4
]}

Dodd, Seetal ^{[1
,4
,11
]}

Scott, James G. ^{[12
,13
]}

Khoo, Jon-Paul ^{[1
,12
]}

Walder, Ken ^{[5
]}

Sarris, Jerome ^{[14
]}

Berk, Michael ^{[1
,2
,4
,11
,15
]}

机构：

[1] Deakin Univ, Barwon Hlth, IMPACT Strateg Res Ctr, Sch Med, Geelong, Vic, Australia

[2] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia

[3] Univ Melbourne, Dept Psychiat, Professorial Unit, Melbourne Clin, Richmond, Vic, Australia

[4] Univ Melbourne, Royal Melbourne Hosp, Dept Psychiat, Parkville, Vic, Australia

[5] Deakin Univ, Sch Med, Ctr Mol & Med Res, Geelong, Vic, Australia

[6] Univ Melbourne, Albert Rd Clin, Professorial Psychiat Unit, Melbourne, Vic, Australia

[7] North West Univ, Sch Pharm Pharmacol, Ctr Excellence Pharmaceut Sci, Potchefstroom, South Africa

[8] Pk Ctr Mental Hlth, Queensland Ctr Mental Hlth Res, Wacol, Qld, Australia

[9] Univ Queensland, Queensland Brain Inst, St Lucia, Qld, Australia

[10] Aarhus Univ, Natl Ctr Register Based Res, Aarhus, Denmark

[11] Univ Melbourne, Ctr Youth Mental Hlth, Parkville, Vic, Australia

[12] Univ Queensland, Fac Med, Herston, Qld, Australia

[13] Royal Brisbane & Womens Hosp, Metro North Mental Hlth, Brisbane, Qld, Australia

[14] Western Sydney Univ, NICM Hlth Res Inst, Westmead, NSW, Australia

[15] Orygen Youth Hlth Res Ctr, Parkville, Vic, Australia

来源：

FRONTIERS IN PSYCHIATRY | 2019年 / 10卷

基金：

澳大利亚国家健康与医学研究理事会; 新加坡国家研究基金会; 英国医学研究理事会;

关键词：

mangosteen pericarp; bipolar disorder; schizophrenia; psychiatry; oxidative stress; inflammation; mitochondria; N-ACETYL CYSTEINE; GARCINIA-MANGOSTANA; ALPHA-MANGOSTIN; OXIDATIVE STRESS; DOUBLE-BLIND; MITOCHONDRIAL DYSFUNCTION; ANTIINFLAMMATORY ACTIVITY; DOPAMINE HYPOTHESIS; NITRIC-OXIDE; KAPPA-B;

D O I：

10.3389/fpsyt.2019.00115

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

New treatments are urgently needed for serious mental illnesses including bipolar disorder and schizophrenia. This review proposes that Garcinia mangostana Linn. (mangosteen) pericarp is a possible adjunctive therapeutic agent for these disorders. Research to date demonstrates that neurobiological properties of the mangosteen pericarp are well aligned with the current understanding of the pathophysiology of bipolar disorder and schizophrenia. Mangosteen pericarp has antioxidant, putative neuroprotective, anti-inflammatory, and putative mitochondrial enhancing properties, with animal studies demonstrating favorable pharmacotherapeutic benefits with respect to these disorders. This review summarizes evidence of its properties and supports the case for future studies to assess the utility of mangosteen pericarp as an adjunctive treatment option for mood and psychotic disorders.

引用

页数：17

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