Glycopolymer ornamented octa-arm POSS based organic-inorganic hybrid star block copolymer as a lectin binding ligand

被引：6
作者：
Bhattacharya, Koushik [1 ]
Banerjee, Sovan Lal [1 ]
Kundu, Moumita [2 ]
Mandal, Mahitosh [2 ]
Singha, Nikhil K. [1 ,3 ]
机构：
[1] Indian Inst Technol, Rubber Technol Ctr, Kharagpur 721302, W Bengal, India
[2] Indian Inst Technol, Sch Med Sci & Technol, Kharagpur 721302, W Bengal, India
[3] Indian Inst Technol, Sch Nanosci & Technol, Kharagpur 721302, W Bengal, India
来源：
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2020年 / 116卷
关键词：
Star glycopolymer; Octa(3-hydroxy-3-methylbutyl dimethylsiloxy); POSS; RAFT polymerization; Lectin-binding; RADICAL POLYMERIZATION; DRUG-DELIVERY; RECOGNITION; POLY(EPSILON-CAPROLACTONE); NANOPARTICLES; MICELLES; POLYMERS; BEHAVIOR; ACID);
D O I：
10.1016/j.msec.2020.111210
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
In this study, a polyhedral oligomeric silsesquioxane-polycaprolactone (POSS-PCL)-cored octa-arm star-shaped glyco block copolymer (BCP), poly(epsilon-caprolactone)-b-poly(glucopyranose) (Star-POSS-PCL-b-PGlc) was successfully synthesized via the combination of ring opening polymerization (ROP) and MADIX (macromolecular design by interchange of xanthate) polymerization technique. Herein, initially octa(3-hydroxy-3-methylbutyl dimethylsiloxy) POSS (Star-POSS) was utilized to initiate the ROP of the epsilon-caprolactone to get octa-arm star-shaped Star-POSS-PCL. A successive bromination followed by xanthation of the synthesized Star-POSS-PCL polymer allowed us to further polymerize 3-O-acryloyl-1,2:5,6 di-O-isopropylidene-alpha-D-glucofuranose (AIpGlc) via MADIX polymerization. Formation of the star-shaped block copolymer (BCP) was characterized using H-1 NMR, FT-IR and DSC analyses. The morphology and the aqueous solution behavior of the Star-POSS-PCL-b-PGlc were analyzed using FESEM, HRTEM and DLS analyses, respectively. The lectin-binding efficiency of the star-shaped BCP having different glycopolymer block length was studied using turbidimetry assay and fluorescence quenching titration (FQT) using photoluminescence spectroscopy (PL). Here, FITC labeled concanavalin A (FITC-Con A) was used as a model lectin. The cytotoxicity study of the star-shaped BCPs over the human fibroblast cells revealed the non-toxic nature of the BCPs which open up its great potential towards drug delivery vector.
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页数：11
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