Finding the Balance: The Role of S-adenosylmethionine and Phosphatidylcholine Metabolism in Development of Nonalcoholic Fatty Liver Disease

被引:46
作者
Jacobs, Rene L. [1 ,2 ]
van der Veen, Jelske N. [2 ,3 ]
Vance, Dennis E. [2 ,3 ]
机构
[1] Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB T6G 2G3, Canada
[2] Univ Alberta, Grp Mol & Cell Biol Lipids, Edmonton, AB T6G 2G3, Canada
[3] Univ Alberta, Dept Biochem, Edmonton, AB T6G 2G3, Canada
关键词
METHIONINE METABOLISM; MICE; TRIACYLGLYCEROL; CHOLINE; MAMMALS; RATIO;
D O I
10.1002/hep.26499
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
[No abstract available]
引用
收藏
页码:1207 / 1209
页数:3
相关论文
共 16 条
[1]  
CANTONI GL, 1953, J BIOL CHEM, V204, P403
[2]   Molecular distinction of phosphatidylcholine synthesis between the CDP-choline pathway and phosphatidylethanolamine methylation pathway [J].
DeLong, CJ ;
Shen, YJ ;
Thomas, MJ ;
Cui, Z .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (42) :29683-29688
[3]   METHIONINE METABOLISM IN MAMMALS - CONCENTRATION OF METABOLITES IN RAT-TISSUES [J].
FINKELSTEIN, JD ;
KYLE, WE ;
HARRIS, BJ ;
MARTIN, JJ .
JOURNAL OF NUTRITION, 1982, 112 (05) :1011-1018
[4]   METHIONINE METABOLISM IN MAMMALS [J].
FINKELSTEIN, JD .
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 1990, 1 (05) :228-237
[5]   Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity [J].
Fu, Suneng ;
Yang, Ling ;
Li, Ping ;
Hofmann, Oliver ;
Dicker, Lee ;
Hide, Winston ;
Lin, Xihong ;
Watkins, Steven M. ;
Ivanov, Alexander R. ;
Hotamisligil, Goekhan S. .
NATURE, 2011, 473 (7348) :528-531
[6]   The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis [J].
Li, Zhaoyu ;
Agellon, Luis B. ;
Allen, Theresa M. ;
Umeda, Masato ;
Jewel, Larry ;
Mason, Andrew ;
Vance, Dennis E. .
CELL METABOLISM, 2006, 3 (05) :321-331
[7]   Hepatic ratio of phosphatidylcholine to phosphatidylethanolamine predicts survival after partial hepatectomy in mice [J].
Ling, Ji ;
Chaba, Todd ;
Zhu, Lin-Fu ;
Jacobs, Rene L. ;
Vance, Dennis E. .
HEPATOLOGY, 2012, 55 (04) :1094-1102
[8]   Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation [J].
Lu, SC ;
Alvarez, L ;
Huang, ZZ ;
Chen, LX ;
An, W ;
Corrales, FJ ;
Avila, MA ;
Kanel, G ;
Mato, JM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (10) :5560-5565
[9]   Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice [J].
Martinez-Chantar, M. Luz ;
Vazquez-Chantada, Mercedes ;
Ariz, Usue ;
Martinez, Nuria ;
Varela, Marta ;
Luka, Zigmund ;
Capdevila, Antonieta ;
Rodriguez, Juan ;
Aransay, Ana M. ;
Matthiesen, Rune ;
Yang, Heping ;
Calvisi, Diego F. ;
Esteller, Manel ;
Fraga, Mario ;
Lu, Shelly C. ;
Wagner, Conrad ;
Mato, Jose M. .
HEPATOLOGY, 2008, 47 (04) :1191-1199
[10]   Excess S-adenosylmethionine Reroutes Phosphatidylethanolamine Towards Phosphatidylcholine and Triglyceride Synthesis [J].
Martinez-Una, Maite ;
Varela-Rey, Marta ;
Cano, Ainara ;
Fernandez-Ares, Larraitz ;
Beraza, Naiara ;
Aurrekoetxea, Igor ;
Martinez-Arranz, Ibon ;
Garcia-Rodriguez, Juan L. ;
Buque, Xabier ;
Mestre, Daniela ;
Luka, Zigmund ;
Wagner, Conrad ;
Alonso, Cristina ;
Finnell, Richard H. ;
Lu, Shelly C. ;
Luz Martinez-Chantar, M. ;
Aspichueta, Patricia ;
Mato, Jose M. .
HEPATOLOGY, 2013, 58 (04) :1296-1305