Proteomics Research in Cardiovascular Medicine and Biomarker Discovery

被引：72

作者：

Lam, Maggie P. Y. ^{[1
,2
]}

Ping, Peipei ^{[1
,2
]}

Murphy, Elizabeth ^{[3
]}

机构：

[1] Univ Calif Los Angeles, NIH Ctr Excellence BD2K, Los Angeles, CA USA

[2] Univ Calif Los Angeles, Dept Physiol Med & Bioinformat, Los Angeles, CA USA

[3] NHLBI, Syst Biol Ctr, NIH, Bldg 10, Bethesda, MD 20892 USA

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2016年 / 68卷 / 25期

关键词：

mass spectrometry; molecular phenotyping; post-translational modifications; protein arrays; protein dynamics; protein signatures; RESOLUTION MASS-SPECTROMETRY; EPSILON SIGNALING COMPLEXES; HUMAN PLASMA PROTEOME; CARDIAC TROPONIN-I; MYOCARDIAL-INFARCTION; S-NITROSYLATION; AFFINITY PURIFICATION; GENE-EXPRESSION; EARLY-DIAGNOSIS; HEART-DISEASE;

D O I：

10.1016/j.jacc.2016.10.031

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Proteomics is a systems physiology discipline to address the large-scale characterization of protein species within a biological system, be it a cell, a tissue, a body biofluid, an organism, or a cohort population. Building on advances from chemical analytical platforms (e.g., mass spectrometry and other technologies), proteomics approaches have contributed powerful applications in cardiovascular biomedicine, most notably in: 1) the discovery of circulating protein biomarkers of heart diseases from plasma samples; and 2) the identification of disease mechanisms and potential therapeutic targets in cardiovascular tissues, in both preclinical models and translational studies. Contemporary proteomics investigations offer powerful means to simultaneously examine tens of thousands of proteins in various samples, and understand their molecular phenotypes in health and disease. This concise review introduces study design considerations, example applications and use cases, as well as interpretation and analysis of proteomics data in cardiovascular biomedicine. Published by Elsevier on behalf of the American College of Cardiology Foundation.

引用

页码：2819 / 2830

页数：12

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