Immunostimulatory activity of polysaccharides from Cheonggukjang

被引：38

作者：

Lee, Seung-Jun ^{[1
,2
]}

Rim, Hong-Kun ^{[1
]}

Jung, Ji-Yun ^{[1
,2
]}

An, Hyo-Jin ^{[1
]}

Shin, Ji-Sun ^{[1
]}

Cho, Chang-Won ^{[3
]}

Rhee, Young Kyoung ^{[3
]}

Hong, Hee-Do ^{[3
]}

Lee, Kyung-Tae ^{[1
,2
]}

机构：

[1] Kyung Hee Univ, Coll Pharm, Dept Pharmaceut Biochem, Seoul 130701, South Korea

[2] Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Seoul 130701, South Korea

[3] Korea Food Res Inst, Kyunggido 463836, Seongnam, South Korea

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2013年 / 59卷

关键词：

Cheonggukjang; Polysaccharide; Immunostimulatory activity; Macrophage; Forced swimming test; NF-KAPPA-B; TUMOR-NECROSIS-FACTOR; FORCED SWIM TEST; NITRIC-OXIDE; STRUCTURAL-CHARACTERIZATION; ENDOTHELIAL-CELLS; IMMUNE-RESPONSES; IN-VITRO; KINASE; SUPPRESSION;

D O I：

10.1016/j.fct.2013.06.045

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Cheonggukjang is a Korean whole soybean paste fermented by Bacillus subtilis and regarded as a healthy food. The objective of this study was to investigate the immunostimulatory activity of polysaccharides from Cheonggukjang (PSCJ) in RAW 264.7 macrophages and an animal model. PSCJ induced mRNA expressions of inducible nitric oxide synthase and tumor necrosis factor-alpha (TNF-alpha) by activating nuclear factor-kappa B, and subsequently increased the productions of nitric oxide (NO) and TNF-alpha in murine recombinant interferon-gamma-primed RAW 264.7 macrophages. Furthermore, after daily oral administration of PSCJ, immobility time decreased significantly in the PSCJ-administered group (200 or 400 mg/kg) on day 10. Taken together, these results suggest that the PSCJ has a possible role improving immune function through regulatory effects on immunological parameters, such as NO and TNF-alpha productions and changes in indicators related to fatigue. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：476 / 484

页数：9

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