Mouse germ cell development during embryogenesis

被引：51
作者：
Saga, Yumiko [1 ]
机构：
[1] Grad Univ Adv Studies SOKENDAI, Natl Inst Genet, Div Mammalian Dev, Mishima, Shizuoka 4118540, Japan
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2008年 / 18卷 / 04期
关键词：
D O I：
10.1016/j.gde.2008.06.003
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The discrimination and differentiation of germ cells from somatic cells is a fundamental issue during development. The early specification of mouse primordial germ cells (PGCs) is achieved by the induction of Blimp1, a key regulator of germ cells. Nanos3 is one of the genes activated in early PGCs and prevents apoptosis during their migration stage. Once PGCs enter the embryonic gonads, they differentiate according to the somatic sex of the organism. During this process, Nanos2 plays an important role as it promotes male germ cell pathway by suppressing the female fate. In this review, the process of germ cell development in the mouse is discussed with a particular focus on the functions of the key proteins, Blimp1, Nanos, and Dead end1.
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收藏
页码：337 / 341
页数：5
相关论文
共 39 条
[1]   Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells [J].
Ancelin, Katia ;
Lange, Ulrike C. ;
Hajkova, Petra ;
Schneider, Robert ;
Bannister, Andrew J. ;
Kouzarides, Tony ;
Surani, M. Azim .
NATURE CELL BIOLOGY, 2006, 8 (06) :623-630
[2]   In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication [J].
Baltus, Andrew E. ;
Menke, Douglas B. ;
Hu, Yueh-Chiang ;
Goodheart, Mary L. ;
Carpenter, Anne E. ;
de Rooij, Dirk G. ;
Page, David C. .
NATURE GENETICS, 2006, 38 (12) :1430-1434
[3]  
BESMER P, 1993, DEVELOPMENT S, V119, P125
[4]   Retinoid signaling determines germ cell fate in mice [J].
Bowles, J ;
Knight, D ;
Smith, C ;
Wilhelm, D ;
Richman, J ;
Mamiya, S ;
Yashiro, K ;
Chawengsaksophak, K ;
Wilson, MJ ;
Rossant, J ;
Hamada, H ;
Koopman, P .
SCIENCE, 2006, 312 (5773) :596-600
[5]   Tdrd1/Mtr-1, a tudor-related gene, is essential for male germ-cell differentiation and nuage/germinal granule formation in mice [J].
Chuma, Shinichiro ;
Hosokawa, Mihoko ;
Kitamura, Kouichi ;
Kasai, Shinya ;
Fujioka, Makio ;
Hiyoshi, Masateru ;
Takamune, Kazufurni ;
Noce, Toshiaki ;
Nakatsuji, Norio .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (43) :15894-15899
[6]   X chromosome activity in mouse XX primordial germ cells [J].
Chuva de Sousa Lopes, Susana M. ;
Hayashi, Katsuhiko ;
Shovlin, Tanya C. ;
Mifsud, Will ;
Surani, M. Azim ;
McLaren, Anne .
PLOS GENETICS, 2008, 4 (02)
[7]   REQUIREMENT FOR MAST-CELL GROWTH-FACTOR FOR PRIMORDIAL GERM-CELL SURVIVAL IN CULTURE [J].
DOLCI, S ;
WILLIAMS, DE ;
ERNST, MK ;
RESNICK, JL ;
BRANNAN, CI ;
LOCK, LF ;
LYMAN, SD ;
BOSWELL, HS ;
DONOVAN, PJ .
NATURE, 1991, 352 (6338) :809-811
[8]   OSKAR ORGANIZES THE GERM PLASM AND DIRECTS LOCALIZATION OF THE POSTERIOR DETERMINANT NANOS [J].
EPHRUSSI, A ;
DICKINSON, LK ;
LEHMANN, R .
CELL, 1991, 66 (01) :37-50
[9]   Chemoattractant action and molecular signaling pathways of Kit ligand on mouse primordial germ cells [J].
Farini, Donatella ;
La Sala, Gina ;
Tedesco, Marianna ;
De Felici, Massimo .
DEVELOPMENTAL BIOLOGY, 2007, 306 (02) :572-583
[10]   EFFECTS OF THE STEEL GENE-PRODUCT ON MOUSE PRIMORDIAL GERM-CELLS IN CULTURE [J].
GODIN, I ;
DEED, R ;
COOKE, J ;
ZSEBO, K ;
DEXTER, M ;
WYLIE, CC .
NATURE, 1991, 352 (6338) :807-809
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