Protein tyrosine phosphatases in T-cell development, apoptosis and signalling

被引：37
作者：
Frearson, JA
Alexander, DR
机构：
[1] T-Cell Laboratory, Dept. of Immunology, Babraham Institute
来源：
IMMUNOLOGY TODAY | 1996年 / 17卷 / 08期
关键词：
D O I：
10.1016/0167-5699(96)10026-8
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The study of phosphatases was viewed as a rather esoteric subject for immunologists until eight years ago, when the discovery that CD45 is a protein tyrosine phosphatase (PTPase) began to make the topic respectable. Now, as reviewed by Julie Frearson and Denis Alexander, PTPases are increasingly being shown to play key roles in the molecular physiology of haematopoietic cells and some have been shown to regulate critical events in T-cell development and signalling.
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页码：385 / 391
页数：7
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