Introduction of a New Magnetic Nanocatalyst as an Organic-inorganic Hybrid Framework for the Synthesis of Pyrano[2,3-d]pyrimidinone(thione)s and Pyrido[2,3-d]pyrimidines

In this work, the preparation of bis-[(3-aminopropyl)triethoxysilane]dichloride immobilized on magnetic nano gamma-Fe2O3@SiO2 is reported. This reagent can be obtained via the reaction of two molecules of 3-aminopropyl)triethoxysilane with 1,4-dichlorobutane followed by immobilization of the resulted di-cationic compound on silica coated nano gamma-Fe2O3. After characterization using FT-IR, XRD, FE-SEM and TGA techniques, the prepared reagent was used as a highly efficient catalyst for the promotion of the synthesis of pyrano[2,3-d]pyrimidinones (thiones) and pyrido[2,3-d]pyrimidine derivatives. The rates and especially the yields of the reactions were excellent in comparison to the reported catalyst for these reactions. Also, the recovery and reusability of the catalyst were excellent for both of the reactions using an external magnet.