Cyclometallation of Heterocycles: A Reliable Strategy for Selective Functionalization

被引：25

作者：

Cuesta, Luciano ^{[1
]}

Urriolabeitia, Esteban P. ^{[1
]}

机构：

[1] Univ Zaragoza, CSIC, Inst Sintesis Quim & Catalisis Homogenea, E-50009 Zaragoza, Spain

来源：

COMMENTS ON INORGANIC CHEMISTRY | 2012年 / 33卷 / 1-2期

关键词：

chelation-assisted functionalization; cyclometallation; directing group; functionalization; heterocycle; metallacycle; palladium; regioselectivity; rhodium; ruthenium; C-H BOND; CATALYZED DIRECT ARYLATION; HETEROARENE CARBOXYLIC-ACIDS; N-H; CRYSTAL-STRUCTURE; HETEROAROMATIC-COMPOUNDS; PLATINUM COMPLEXES; PHOTOPHYSICAL PROPERTIES; RUTHENIUM(II) COMPLEXES; NITROGEN-HETEROCYCLES;

D O I：

10.1080/02603594.2012.700971

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Heterocyclic compounds are of paramount importance in essentially all fields of chemistry and in our daily life. Therefore, the synthesis and modification of such compounds is a constantly expanding field in synthetic chemistry. Recent developments of functionalization of heterocycles by means of cyclometallation (also called chelation-assisted functionalization), both stoichiometric and catalytic, indicate that this strategy displays enormous potential. In particular, this method facilitates considerably the synthesis of functionalized heterocycles in a regioselective (site-selective) manner, and also provides novel types of synthetic transformations.

引用

页码：55 / 85

页数：31

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