PACAP/PKA reduces polyglutamine androgen receptor toxicity in cell models of spinal and bulbar muscular atrophy

被引:0
作者
Pennuto, M. [1 ]
Parodi, S. [1 ]
Contestabile, A. [1 ]
Gozes, I. [2 ]
Sambataro, F. [3 ]
机构
[1] Ist Italiano Tecnol, Dept Neurosci & Brain Technol, I-16163 Genoa, Italy
[2] Tel Aviv Univ, Sch Neurosci,Sackler Fac Med,Adams Super Ctr Brai, Lily & Avraham Gildor Chair Invest Growth Factors, Dept Human Mol Genet & Biochem,Elton Lab Neuroend, IL-69978 Tel Aviv, Israel
[3] UniPr, Ist Italiano Tecnol, Brain Ctr Social & Motor Cognit, I-43100 Parma, Italy
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中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
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页码:S143 / S143
页数:1
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[31]   Transcriptional activation by the androgen receptor in X-linked spinal and bulbar muscular atrophy [J].
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