Free radical oxidation and activity of enzymes catalyzing biotransformation of xenobiotics in the liver of rats with experimental acute pancreatitis

被引：3

作者：

Shabanov, VI ^{[1
]}

Sarbaeva, NN ^{[1
]}

Milyakova, MN ^{[1
]}

Detyuchenko, VP ^{[1
]}

机构：

[1] Samara Mil Med Inst, Dept Surg, Samara, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2001年 / 132卷 / 02期

关键词：

pancreatitis; liver; lipid peroxidation; antioxidant protection; detoxifying enzymes;

D O I：

10.1023/A:1013077811544

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The development of experimental acute pancreatitis in rats was accompanied by intensification of lipid peroxidation, activation of superoxide dismutase and glutathione reductase, inhibition of glutathione transferase, and deceleration of aniline N-hydroxylation by cytochrome P-450 in the liver. Antioxidants inhibited lipid peroxidation and antioxidant enzymes, but did not prevent inhibition of detoxifying enzymes.

引用

页码：754 / 756

页数：3

共 11 条

[1]

Archacov, 1972, LIPID PEROXIDATION B

[2] Free radicals generated by xanthine oxidase mediate pancreatitis-associated organ failure [J].