Investigation of False-Positive Results Given by the QuantiFERON-TB Gold In-Tube Assay

被引:31
作者
Slater, Madeline [1 ]
Parsonnet, Julie [1 ]
Banaei, Niaz [1 ,2 ,3 ]
机构
[1] Stanford Univ Sch Med, Div Infect Dis & Geog Med, Dept Med, Palo Alto, CA USA
[2] Stanford Univ Sch Med, Div Infect Dis & Geog Med, Dept Pathol, Palo Alto, CA USA
[3] Stanford Univ Med Ctr, Clin Microbiol Lab, Palo Alto, CA USA
关键词
D O I
10.1128/JCM.00730-12
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
We investigated a sudden increase in the rate of positive QuantiFERON-TB Gold In-Tube results from 10% to 31% at a U. S. academic institution. Direct comparison of the TB antigen tubes with tubes from a different lot number identified that a potential problem with the TB antigen vials in a certain tube lot was the likely cause of the elevated positive rate. The underlying defect remains unknown. This finding warrants refinement of quality control programs by the manufacturer and users.
引用
收藏
页码:3105 / 3107
页数:3
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