Epigenetics and human disease: translating basic biology into clinical applications

被引：290
作者：
Rodenhiser, D
Mann, M
机构：
[1] Univ Western Ontario, Dept Paediat, London, ON N6A 4L6, Canada
[2] Univ Western Ontario, Childrens Hlth Res Inst, EpiGenWestern Res Grp, London, ON N6A 4L6, Canada
[3] Univ Western Ontario, Dept Biochem, London, ON N6A 4L6, Canada
[4] Univ Western Ontario, Dept Oncol, London, ON N6A 4L6, Canada
[5] Univ Western Ontario, Dept Obstet & Gynecol, London, ON N6A 4L6, Canada
[6] London Hlth Sci Ctr, London Reg Canc Program, London, ON, Canada
来源：
CANADIAN MEDICAL ASSOCIATION JOURNAL | 2006年 / 174卷 / 03期
关键词：
D O I：
10.1503/cmaj.050774
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Epigenetics refers to the study of heritable changes in gene expression that occur without a change in DNA sequence. Research has shown that epigenetic mechanisms provide an "extra" layer of transcriptional control that regulates how genes are expressed. These mechanisms are critical components in the normal development and growth of cells. Epigenetic abnormalities have been found to be causative factors in cancer, genetic disorders and pediatric syndromes as well as contributing factors in autoimmune diseases and aging. In this review, we examine the basic principles of epigenetic mechanisms and their contribution to human health as well as the clinical consequences of epigenetic errors. In addition, we address the use of epigenetic pathways in new approaches to diagnosis and targeted treatments across the clinical spectrum.
引用
收藏
页码：341 / 348
页数：8
相关论文
共 107 条
[1]   Methylomics in psychiatry: Modulation of gene-environment interactions may be through DNA methylation [J].
Abdolmaleky, HM ;
Smith, CL ;
Faraone, SV ;
Shafa, R ;
Stone, W ;
Glatt, SJ ;
Tsuang, MT .
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2004, 127B (01) :51-59
[2]   Epigenetics and nuclear transfer [J].
Alberio, R ;
Campbell, KHS .
LANCET, 2003, 361 (9365) :1239-1240
[3]   X-chromosome inactivation: Counting, choice and initiation [J].
Avner, P ;
Heard, E .
NATURE REVIEWS GENETICS, 2001, 2 (01) :59-67
[4]   New anti-cancer strategies: Epigenetic therapies and biomarkers [J].
Balch, C ;
Montgomery, JS ;
Paik, HI ;
Kim, S ;
Huang, THM ;
Nephew, KP .
FRONTIERS IN BIOSCIENCE-LANDMARK, 2005, 10 :1897-1931
[5]   Complex imprinting [J].
Beaudet, AL .
NATURE GENETICS, 2004, 36 (08) :793-795
[6]   Hypermethylation of the DNA repair gene MGMT:: association with TP53 G:C to A:T transitions in a series of 469 nervous system tumors [J].
Bello, MJ ;
Alonso, ME ;
Amiñoso, C ;
Anselmo, NP ;
Arjona, D ;
Gonzalez-Gomez, P ;
Lopez-Marin, I ;
de Campos, JM ;
Gutierrez, M ;
Isla, A ;
Kusak, ME ;
Lassaletta, L ;
Sarasa, JL ;
Vaquero, J ;
Casartelli, C ;
Rey, JA .
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2004, 554 (1-2) :23-32
[7]   A stepwise epigenetic process controls immunoglobulin allelic exclusion [J].
Bergman, Y ;
Cedar, H .
NATURE REVIEWS IMMUNOLOGY, 2004, 4 (10) :753-761
[8]   The cell-specific expression of endothelial nitric-oxide synthase - A role for DNA methylation [J].
Chan, Y ;
Fish, JE ;
D'Abreo, C ;
Lin, S ;
Robb, GB ;
Teichert, AM ;
Karantzoulis-Fegaras, F ;
Keightley, A ;
Steer, BM ;
Marsden, PA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (33) :35087-35100
[9]   On the epigenetic regulation of the human reelin promoter [J].
Chen, Y ;
Sharma, RP ;
Costa, RH ;
Costa, E ;
Grayson, DR .
NUCLEIC ACIDS RESEARCH, 2002, 30 (13) :2930-2939
[10]   Methylation profiling in multiple myeloma [J].
Chim, CS ;
Kwong, YL ;
Fung, TK ;
Liang, R .
LEUKEMIA RESEARCH, 2004, 28 (04) :379-385
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