Iterative, aqueous synthesis of β3-oligopeptides without coupling reagents

被引：77

作者：

Carrillo, N ^{[1
]}

Davalos, EA ^{[1
]}

Russak, JA ^{[1
]}

Bode, JW ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 05期

关键词：

D O I：

10.1021/ja057706j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The chemoselective synthesis of amides by decarboxylative couplings of α-ketoacids and isoxazolidines makes possible an iterative approach to poly-β3-peptides. Peptide assembly occurs under aqueous conditions and requires no coupling reagents. The requisite isoxazolidine monomers are prepared in enantiopure form by a convenient two-step protocol starting from the appropriate aldehydes. Copyright © 2006 American Chemical Society.

引用

页码：1452 / 1453

页数：2

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