Iterative, aqueous synthesis of β3-oligopeptides without coupling reagents

被引：77
作者：
Carrillo, N [1 ]
Davalos, EA [1 ]
Russak, JA [1 ]
Bode, JW [1 ]
机构：
[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 05期
关键词：
D O I：
10.1021/ja057706j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The chemoselective synthesis of amides by decarboxylative couplings of α-ketoacids and isoxazolidines makes possible an iterative approach to poly-β3-peptides. Peptide assembly occurs under aqueous conditions and requires no coupling reagents. The requisite isoxazolidine monomers are prepared in enantiopure form by a convenient two-step protocol starting from the appropriate aldehydes. Copyright © 2006 American Chemical Society.
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页码：1452 / 1453
页数：2
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