Antigenic Patterns and Evolution of the Human Influenza A (H1N1) Virus

被引：50

作者：

Liu, Mi ^{[1
,2
,3
,4
]}

Zhao, Xiang ^{[5
]}

Hua, Sha ^{[4
,6
]}

Du, Xiangjun ^{[7
]}

Peng, Yousong ^{[8
]}

Li, Xiyan ^{[5
]}

Lan, Yu ^{[5
]}

Wang, Dayan ^{[5
]}

Wu, Aiping ^{[1
,2
,3
,4
]}

Shu, Yuelong ^{[5
]}

Jiang, Taijiao ^{[1
,2
,3
,4
]}

机构：

[1] Chinese Acad Med Sci, Inst Basic Med Sci, Ctr Syst Med, Beijing 100005, Peoples R China

[2] Peking Union Med Coll, Beijing 100005, Peoples R China

[3] Suzhou Inst Syst Med, Suzhou 215123, Peoples R China

[4] Chinese Acad Sci, Key Lab Prot & Peptide Pharmaceut, Inst Biophys, Beijing 100101, Peoples R China

[5] China CDC, Natl Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China

[6] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[7] Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA

[8] Hunan Univ, Coll Informat Sci & Engn, Changsha 410082, Hunan, Peoples R China

来源：

SCIENTIFIC REPORTS | 2015年 / 5卷

基金：

中国国家自然科学基金;

关键词：

GLOBAL CIRCULATION; UNITED-STATES; HEMAGGLUTININ; ALGORITHM; STRAINS; MODELS;

D O I：

10.1038/srep14171

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The influenza A (H1N1) virus causes seasonal epidemics that result in severe illnesses and deaths almost every year. A deep understanding of the antigenic patterns and evolution of human influenza A (H1N1) virus is extremely important for its effective surveillance and prevention. Through development of antigenicity inference method for human influenza A (H1N1), named PREDAC-H1, we systematically mapped the antigenic patterns and evolution of the human influenza A (H1N1) virus. Eight dominant antigenic clusters have been inferred for seasonal H1N1 viruses since 1977, which demonstrated sequential replacements over time with a similar pattern in Asia, Europe and North America. Among them, six clusters emerged first in Asia. As for China, three of the eight antigenic clusters were detected in South China earlier than in North China, indicating the leading role of South China in H1N1 transmission. The comprehensive view of the antigenic evolution of human influenza A (H1N1) virus can help formulate better strategy for its prevention and control.

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