Validation of neuroradiologic response assessment in gliomas: Measurement by RECIST, two-dimensional, computer-assisted tumor area, and computer-assisted tumor volume methods

被引:108
作者
Galanis, E
Buckner, JC
Maurer, MJ
Sykora, R
Castillo, R
Ballman, KV
Erickson, BJ
机构
[1] Mayo Clin, Div Med Oncol, Rochester, MN 55905 USA
[2] Mayo Clin, Div Biostat, Rochester, MN 55905 USA
[3] Mayo Clin, Dept Radiol, Rochester, MN 55905 USA
[4] Alton Ochsner Med Fdn & Ochsner Clin, New Orleans, LA 70121 USA
关键词
gliomas; Response Evaluation Criteria in Solid Tumors (RECIST); tumor response; WHO criteria;
D O I
10.1215/15228517-2005-005
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Significant limitations are associated with the use of standard radiographic measurements as indicators of response In glioma therapy trials. The Response Evaluation Criteria in Solid Tumors (RECIST) were recently introduced in an attempt to standardize and simplify assessment of response to treatment in cancer clinical trials. However, their applicability in gliomas has been assessed in only a very small number of patients. Our aim was to validate radiographic response assessment in newly diagnosed glioma patients. Sixty-seven newly diagnosed glioma patients participating in nine North Central Cancer Treatment Group glioma trials were included; 565 MRI scans were analyzed. All scans were performed with the same technique. Kappa statistics were calculated to determine agreement between assessment methods. Cox proportional hazards analyses and time-dependent Cox models were used to assess the association between different measurement methods and overall survival. Results showed agreement between the one-dimensional (1D) and two-dimensional (2D) measurements both for T2 images and for gadolinium-enhanced images. Comparison of duration of response and time to progression as assessed by eight different methods showed similarity in response assessments by 1D, 2D, area, and volume gadolinium measurements. In contrast, time to progression was significantly shorter when assessed by 1D-T2 or 2D-T2 images as compared to area-T2 or volume-T2 images. This set of data indicates that RECIST could be used instead of 2D imaging for response assessment in newly diagnosed glioma trials. Overall, responses as determined by any tumor measurement method did not correlate with patient survival for either enhancing or nonenhancing tumors, although the small number of responders limits definitive conclusions. Time-dependent Cox models demonstrated that, in contrast to the case of nonenhancing tumors, progression as determined by 1D, 2D, area, and volume measurements in gadolinium-enhanced images was predictive of survival of patients with enhancing tumors.
引用
收藏
页码:156 / 165
页数:10
相关论文
共 29 条
[1]   Chemotherapy of high grade gliomas: Beginning of a new era or the end of the old? [J].
Brada, M ;
Sharpe, G .
EUROPEAN JOURNAL OF CANCER, 1996, 32A (13) :2193-2194
[2]   Modified RECIST criteria for assessment of response in malignant pleural mesothelioma [J].
Byrne, MJ ;
Nowak, AK .
ANNALS OF ONCOLOGY, 2004, 15 (02) :257-260
[4]   MEASURING MASSES ON CROSS-SECTIONAL IMAGES [J].
FORNAGE, BD .
RADIOLOGY, 1993, 187 (01) :289-289
[5]  
Hess K R, 1999, Neuro Oncol, V1, P282, DOI 10.1093/neuonc/1.4.282
[6]   Analysis of interobserver and intraobserver variability in CT tumor measurements [J].
Hopper, KD ;
Kasales, CJ ;
VanSlyke, MA ;
Schwartz, TA ;
TenHave, TR ;
Jozefiak, JA .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1996, 167 (04) :851-854
[7]   Measuring response in solid tumors: Unidimensional versus bidimensional measurement [J].
James, K ;
Eisenhauer, E ;
Christian, M ;
Terenziani, M ;
Vena, D ;
Muldal, A ;
Therasse, P .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1999, 91 (06) :523-528
[8]   NONPARAMETRIC-ESTIMATION FROM INCOMPLETE OBSERVATIONS [J].
KAPLAN, EL ;
MEIER, P .
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1958, 53 (282) :457-481
[9]  
LAVIN PT, 1980, CANCER, V46, P1286, DOI 10.1002/1097-0142(19800901)46:5<1286::AID-CNCR2820460533>3.0.CO
[10]  
2-F