Development of the BIPI ligands for asymmetric hydrogenation

被引：11

作者：

Busacca, Carl A. ^{[1
]}

Lorenz, Jon C. ^{[1
]}

Saha, Anjan K. ^{[1
]}

Cheekoori, Sreedhar ^{[1
]}

Haddad, Nizar ^{[1
]}

Reeves, Diana ^{[1
]}

Lee, Heewon ^{[1
]}

Li, Zhibin ^{[1
]}

Rodriguez, Sonia ^{[1
]}

Senanayake, Chris H. ^{[1
]}

机构：

[1] Boehringer Ingelheim Pharmaceut Inc, Ridgefield, CT USA

来源：

CATALYSIS SCIENCE & TECHNOLOGY | 2012年 / 2卷 / 10期

关键词：

COMPLEXES; RACEMIZATION; VERSATILE;

D O I：

10.1039/c2cy20337e

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The detailed development of unique BIPI ligands suitable for asymmetric hydrogenation is described, and the process research leading to their kilogram-scale manufacture is discussed. Full optimization of each ligand region is shown, and the complete design features for these ligands are explained. Application of the best members of this ligand class to asymmetric hydrogenations of ureaesters, BOC- and CBZ-enecarbamates, and a variety of enamides are described. A novel resolution of P-chiral ligand precursors via their zinc complexes is described, and the research leading to the discovery of catalysts capable of carrying out asymmetric hydrogenations in >99% ee at multi-kilogram scale are presented.

引用

页码：2083 / 2089

页数：7

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