Base-catalyzed, efficient synthesis of 5-substituted 3,6-dihydro-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-ones

被引：14

作者：

Zhao, JF ^{[1
]}

Xie, C ^{[1
]}

Ding, MW ^{[1
]}

He, HW ^{[1
]}

机构：

[1] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2005年 / 15期

关键词：

pyrimidines; imides; cyclizations; aza-Wittig reactions; heterocycles; guanines;

D O I：

10.1055/s-2005-872077

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The carbodiimides 2, obtained from aza-Wittig reactions of iminophosphorane 1 with aromatic isocyanates, reacted with secondary amines or ROH to give 5-dialkylamino or 5-alkoxy 7H-1,2,3 -triazolo [4,5-d] pyrimidin-7-ones 4 in the presence of a catalytic amount of EtONa in a mixed solvent (CH2Cl2-ROH). Reactions of 2 with phenols in presence of catalytic potassium carbonate in MeCN gave 5-aryloxy-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-ones 4 in satisfactory yields.

引用

收藏

页码：2544 / 2548

页数：5

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