Cortical blindness and seizures in a patient receiving FK506 after bone marrow transplantation

被引：26
作者：
Steg, RE
Kessinger, A
Wszolek, ZK
机构：
[1] Creighton Univ, Sch Med, Dept Neurol, Omaha, NE 68131 USA
[2] Univ Nebraska, Med Ctr, Dept Internal Med, Sect Hematol & Oncol, Omaha, NE USA
[3] Univ Nebraska, Med Ctr, Dept Internal Med, Neurol Sect, Omaha, NE USA
来源：
BONE MARROW TRANSPLANTATION | 1999年 / 23卷 / 09期
关键词：
cortical blindness and seizures; FK506; neurotoxicity; bone marrow transplantation;
D O I：
10.1038/sj.bmt.1701732
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
A 54-year-old woman with a myelodysplastic syndrome treated with high-dose chemotherapy and an allogenic bone marrow transplant developed acute cortical blindness while receiving tacrolimus (FK506). MRI showed white matter abnormalities. After discontinuation of FK506, the patient's vision returned within 8 days. FK506 neurotoxicity is similar to cyclosporine neurotoxicity and can occur in allogenic bone marrow transplant patients treated with FK506.
引用
收藏
页码：959 / 962
页数：4
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