Axonal projections from the organum vasculosum lamina terminalis to the supraoptic nucleus: Functional analysis and presynaptic modulation

被引：22

作者：

Bourque, CW

Richard, D

机构：

[1] Montreal Gen Hosp, Div Neurol, Neurosci Res Ctr, Montreal, PQ H3G 1A4, Canada

[2] McGill Univ, Montreal, PQ, Canada

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 2001年 / 28卷 / 07期

关键词：

alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid; atrial natriuretic peptide; excitation; excitatory postsynaptic potential; glutamate; N-methyl-D-aspartate; presynaptic inhibition;

D O I：

10.1046/j.1440-1681.2001.03488.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The rat organum vasculosum lamina terminalis (OVLT) contains GABA- and glutamate-releasing neurons that project directly to magnocellular neurosecretory cells (MNC) in the supraoptic nucleus. 2. Changes in osmolality over the OVLT in hypothalamic explants cause proportional changes in firing in MNC through corresponding changes in the frequency of spontaneous glutamatergic excitatory post-synaptic potentials without affecting GABAergic inhibitory post-synaptic potentials. 3. Exogenously applied atrial natriuretic peptide inhibits the osmotic control of MNC by causing a decrease in the amount of glutamate released provoked by action potentials originating from OVLT neurons.

引用

页码：570 / 574

页数：5

共 31 条

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