"On Water", Phosphine-Free Palladium-Catalyzed Room Temperature C-H Arylation of Indoles

被引：78

作者：

Islam, Saidul ^{[1
]}

Larrosa, Igor ^{[1
]}

机构：

[1] Queen Mary Univ London, Sch Biol & Chem Sci, London E1 4NS, England

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 45期

基金：

欧洲研究理事会; 英国工程与自然科学研究理事会;

关键词：

arylation; CH functionalization; indoles; palladium; water; DIRECT C-2 ARYLATION; ORGANIC-SYNTHESIS; BOND FUNCTIONALIZATION; (HETERO)ARENES; ACTIVATION; OXAZOLES;

D O I：

10.1002/chem.201302838

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Get on top of your chemistry! An "on water", palladium-catalyzed, phosphine-free direct C-H arylation of indoles, with iodoarenes at 25-30°C, is disclosed (see scheme; TBDMS=N-tert-butyldimethylsilyl ether; SEM=N-2-(trimethylsilyl)ethoxymethyl; Bn=benzyl, Piv=pivabyl). The mildness of the reaction conditions permits the tolerance of a variety of N1-protected indoles. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：15093 / 15096

页数：4

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