Metabolic targets for cancer therapy

被引：583

作者：

Galluzzi, Lorenzo ^{[1
,2
,3
]}

Kepp, Oliver ^{[1
,2
,3
,4
]}

Vander Heiden, Matthew G. ^{[5
,6
]}

Kroemer, Guido ^{[1
,2
,4
,7
,8
]}

机构：

[1] Univ Paris 05, Sorbonne Paris Cite, F-75006 Paris, France

[2] Ctr Rech Cordeliers, Equipe Labellisee Ligue Natl Canc 11, F-75006 Paris, France

[3] Gustave Roussy, F-94805 Villejuif, France

[4] Gustave Roussy, INSERM, U848, F-94805 Villejuif, France

[5] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[6] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA

[7] Gustave Roussy, Metabol & Cell Biol Platforms, F-94805 Villejuif, France

[8] Hop Europeen Georges Pompidou, APHP, Pole Biol, F-75015 Paris, France

来源：

NATURE REVIEWS DRUG DISCOVERY | 2013年 / 12卷 / 11期

基金：

欧洲研究理事会;

关键词：

PYRUVATE-KINASE M2; NF-KAPPA-B; FATTY-ACID OXIDATION; CELL LUNG-CANCER; REDUCTIVE GLUTAMINE-METABOLISM; HISTONE DEACETYLASE SIRT6; BCL-2 PROTEIN FAMILY; RANDOMIZED PHASE-II; HEAT-SHOCK FACTOR-1; ATP-CITRATE LYASE;

D O I：

10.1038/nrd4145

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Malignant cells exhibit metabolic changes, when compared to their normal counterparts, owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has recently been indicated as yet another general hallmark of cancer, accumulating evidence suggests that the metabolic alterations of each neoplasm represent a molecular signature that intimately accompanies and allows for different facets of malignant transformation. During the past decade, targeting cancer metabolism has emerged as a promising strategy for the development of selective antineoplastic agents. Here, we discuss the intimate relationship between metabolism and malignancy, focusing on strategies through which this central aspect of tumour biology might be turned into cancer's Achilles heel.

引用

页码：829 / 846

页数：18

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