α-fetoprotein-producing adenocarcinoma of the pancreas presenting focal hepatoid differentiation

被引：27

作者：

Tanno, S ^{[1
]}

Obara, T ^{[1
]}

Fujii, T ^{[1
]}

Izawa, T ^{[1
]}

Mizukami, Y ^{[1
]}

Saitoh, Y ^{[1
]}

Ura, H ^{[1
]}

Kohgo, Y ^{[1
]}

机构：

[1] Asahikawa Med Coll, Dept Internal Med 3, Asahikawa, Hokkaido 0788510, Japan

来源：

INTERNATIONAL JOURNAL OF PANCREATOLOGY | 1999年 / 26卷 / 01期

关键词：

hepatoid; adenocarcinoma; pancreas; alpha-fetoprotein; metastasis; lymph node;

D O I：

10.1385/IJGC:26:1:43

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a rare case of pancreatic carcinoma producing a-fetoprotein (AFP), showing focal hepatoid differentiation in metastatic lymph nodes. A 65-yr-old female was admitted because of abdominal pain. The serum AFP was measured at 16,170 ng/mL. Radiological examinations revealed a mass measuring 6 cm in diameter in the body and tail of the pancreas. A right supraclavicular lymphadenopathy was found and biopsied. Light microscopy showed a tumor consisting of a portion of a hepatoid area and well-differentiated adenocarcinoma, which was suggestive of a hepatoid adenocarcinoma. Immunohistochemical analysis showed that the tumor cells expressed AFP, alpha(1)-antitrypsin (AT) and albumin. Although the pathological diagnosis of the primary pancreatic tumor was not obtained, this appears to be the first case of hepatoid adenocarcinoma of the pancreas.

引用

页码：43 / 47

页数：5

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