Interferometric focusing of guide-stars for direct wavefront sensing

被引:0
|
作者
Tao, Xiaodong [1 ]
Dean, Ziah [2 ]
Chien, Christopher [3 ]
Azucena, Oscar [1 ]
Kubby, Joel [1 ]
机构
[1] Univ Calif Santa Cruz, Dept Elect Engn, 1156 High St, Santa Cruz, CA 95064 USA
[2] Univ Michigan, Dept Biophys, Ann Arbor, MI 48109 USA
[3] Univ Calif Santa Cruz, Dept Biol, Santa Cruz, CA 95064 USA
来源
MEMS ADAPTIVE OPTICS VII | 2013年 / 8617卷
关键词
Adaptive Optics; Interferometic Focusing; Scattering; Guide-stars; SCATTERING MEDIA; PHASE-CONJUGATION; TURBID MEDIA; LIGHT; ALGORITHM;
D O I
10.1117/12.2006118
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
Optical microscopy allows noninvasive imaging of biological tissues at a subcellular level. However, the optimal performance of the microscope is hard to achieve because of aberrations induced from tissues. The shallow penetration depth and degraded resolution provide a limited degree of information for biologists. In order to compensate for aberrations, adaptive optics with direct wavefront sensing, where guide-stars are used for wavefront measurement, has been applied in microscopy. The scattering effect limits the intensity of a guide-star and hence reduces the signal to noise ratio of the wavefront measurement. In this paper, we propose to use interferometric focusing of excitation light onto a guide-star embedded deeply in tissue to increase its fluorescence intensity, thus overcoming the signal loss caused by scattering. With interferometric focusing of light, we increase the signal to noise ratio of the laser guide-star through scattering tissue by more than two times as well as potentially extending the thickness of tissue that can be corrected using AO microscopy.
引用
收藏
页数:7
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