Investigation on the interaction behavior between curcumin and PAMAM dendrimer by spectral and docking studies

被引：28

作者：

Cao, Jian ^{[1
]}

Zhang, Hongmei ^{[1
]}

Wang, Yanqing ^{[1
]}

Yang, Jinming ^{[1
]}

Jiang, Fuguang ^{[1
]}

机构：

[1] Yancheng Teachers Univ, Inst Appl Chem & Environm Engn, Yancheng City 224002, Jiangsu, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2013年 / 108卷

关键词：

PAMAM-C-12 25%; Curcumin; Fluorescence; Binding mode; Binding sites; DRUG-DELIVERY; FLUORESCENCE; BINDING; ENCAPSULATION; MOLECULES; MODEL; PH;

D O I：

10.1016/j.saa.2013.02.003

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

The interactions between PAMAM-C-12 25% and curcumin were studied by UV/vis, fluorescence spectroscopy, and molecular modeling methods. The experimental results showed that the formation of PAMAM-C-12 25%@curcumin non-covalent adduct induced the fluorescence quenching of PAMAM-C-12 25%; Curcumin entered the interface of PAMAM-C-12 25% with mainly five classes of binding sites by hydrophobic, hydrogen bonds, and van der Waals forces interactions. The bigger values of binding constants indicated that PAMAM-C-12 25% hold the curcumin tightly. (c) 2013 Elsevier B.V. All rights reserved.

引用

页码：251 / 255

页数：5

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