Efficient Synthesis of Pamidronic Acid Using an Ionic Liquid Additive

被引：12
作者：
Grun, Alajos [1 ]
Nagy, David Illes [1 ]
Garadnay, Sandor [2 ]
Greiner, Istvan [2 ]
Keglevich, Gyorgy [1 ]
机构：
[1] Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1521 Budapest, Hungary
[2] Gedeon Richter Plc, H-1475 Budapest, Hungary
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2016年 / 13卷 / 06期
关键词：
Pamidronic acid; best synthesis; additive; ionic liquids; intermediate; BISPHOSPHONATES;
D O I：
10.2174/1570180812666151022221805
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
An efficient method was developed for the synthesis of pamidronic acid involving the reaction of beta-alanine with three equivalents of phosphorus trichloride and two equivalents of phosphorous acid at 75 degrees C in the presence of 0.3 or 0.6 equivalents of [BMIM][PF6] as an additive.
引用
收藏
页码：475 / 478
页数：4
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