Nanoparticle translocation through a lipid bilayer tuned by surface chemistry

被引:65
作者
da Rocha, Edroaldo Lummertz [1 ]
Caramori, Giovanni Finoto [2 ]
Rambo, Carlos Renato [1 ]
机构
[1] Univ Fed Santa Catarina, Grad Program Mat Sci & Engn, Florianpolis, SC, Brazil
[2] Univ Fed Santa Catarina, Dept Chem, Florianpolis, SC, Brazil
关键词
MOLECULAR-DYNAMICS SIMULATIONS; RECEPTOR-MEDIATED ENDOCYTOSIS; GOLD NANOPARTICLES; COMPUTER-SIMULATION; IN-VIVO; DENDRIMERS; MEMBRANES; PENETRATION; ADSORPTION; STRATEGIES;
D O I
10.1039/c2cp44035k
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
An enhanced understanding about the interactions between nanomaterials and cell membranes may have important implications for biomedical applications. In this work, coarse-grained molecular dynamics simulations of gold nanoparticles interacting with lipid bilayers were performed to evaluate the effect of hydrophobicity, charge density and ligand length on lipid bilayers. The simulations accomplished indicate that hydrophobic and anionic nanoparticles do not exhibit significant interactions and different charge densities may induce pore formation or nanoparticle wrapping, resembling first stages of endocytosis. The suggested interplay between charge density and ligand length has important implications when designing nanoparticles for drug and gene delivery applications. Moreover, control of charge densities may induce internalization of nanoparticles into cells through different mechanisms such as passive translocation, for nanoparticles with low charge density, or endocytosis for higher charge densities, highlighting the role of surface chemistry in nanoparticle-cell interactions.
引用
收藏
页码:2282 / 2290
页数:9
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