Highly Sensitive Ammonia Sensor with Organic Vertical Nanojunctions for Noninvasive Detection of Hepatic Injury

被引：91

作者：

Dai, Ming-Zhi ^{[1
,4
]}

Lin, Yi-Lo ^{[2
,3
]}

Lin, Hung-Cheng ^{[4
]}

Zan, Hsiao-Wen ^{[4
]}

Chang, Kai-Ting ^{[3
,5
]}

Meng, Hsin-Fei ^{[1
]}

Liao, Jiunn-Wang ^{[2
]}

Tsai, May-Jywan ^{[3
]}

Cheng, Henrich ^{[3
,5
,6
,7
]}

机构：

[1] Natl Chiao Tung Univ, Inst Phys, Hsinchu, Taiwan

[2] Natl Chung Hsing Univ, Coll Vet Med, Grad Inst Vet Pathobiol, Taichung, Taiwan

[3] Taipei Vet Gen Hosp, Neurol Inst, Dept Neurosurg, Neural Regenerat Lab, Taipei, Taiwan

[4] Natl Chiao Tung Univ, Dept Photon, Hsinchu, Taiwan

[5] Natl Yang Ming Univ, Sch Med, Dept & Inst Pharmacol, Taipei 112, Taiwan

[6] Taipei Vet Gen Hosp, Neurol Inst, Dept Neurosurg, Ctr Neural Regenerat, Taipei, Taiwan

[7] Natl Yang Ming Univ, Sch Med, Brain Res Ctr, Taipei 112, Taiwan

来源：

ANALYTICAL CHEMISTRY | 2013年 / 85卷 / 06期

关键词：

THIN-FILM TRANSISTORS; LIVER-CIRRHOSIS; RENAL-FAILURE; BREATH; RATS; ENCEPHALOPATHY; ENHANCEMENT; ARRAYS;

D O I：

10.1021/ac303100k

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We successfully demonstrate the first solid-state sensor to have reliable responses to breath ammonia of rat. For thioacetamide (TAA)-induced hepatopathy rats, we observe that the proposed sensor can detect liver that undergoes acute-moderate hepatopathy with a p-value less than 0.05. The proposed sensor is an organic diode with vertical nanojunctions produced by using low-cost colloidal lithography. Its simple structure and low production cost facilitates the development of point-of-care technology. We also anticipate that the study is a starting point for investigating sophisticated breath-ammonia-related disease models.

引用

页码：3110 / 3117

页数：8

共 38 条

[1] Breath-Ammonia Testing of Healthy Subjects and Patients with Cirrhosis [J].

Adrover, R. ;

Cocozzella, D. ;

Ridruejo, E. ;

Garcia, A. ;

Rome, J. ;

Podesta, J. J. .

DIGESTIVE DISEASES AND SCIENCES, 2012, 57 (01) :189-195

[2] Breath ammonia sensor based on conducting polymer nanojunctions [J].

Aguilar, Alvaro Diaz ;

Forzani, Erica S. ;

Nagahara, Larry A. ;

Amlani, Islamshah ;

Tsui, Raymond ;

Tao, N. J. .

IEEE SENSORS JOURNAL, 2008, 8 (3-4) :269-273

[3] The scent fingerprint of hepatocarcinoma: in-vitro metastasis prediction with volatile organic compounds (VOCs) [J].

Amal, Haitham ;

Ding, Lu ;

Liu, Bin-bin ;

Tisch, Ulrike ;

Xu, Zhen-qin ;

Shi, Da-you ;

Zhao, Yan ;

Chen, Jie ;

Sun, Rui-xia ;

Liu, Hu ;

Ye, Sheng-Long ;

Tang, Zhao-you ;

Haick, Hossam .

INTERNATIONAL JOURNAL OF NANOMEDICINE, 2012, 7 :4135-4146

[4]

Bain P. J., 2003, DUNCAN PRASSES VET L, P206

[5] A survey of the 2006-2009 quartz crystal microbalance biosensor literature [J].

Becker, Bernd ;

Cooper, Matthew A. .

JOURNAL OF MOLECULAR RECOGNITION, 2011, 24 (05) :754-787

[6] Device physics of organic light-emitting diodes based on molecular materials [J].

Bruetting, Wolfgang ;

Berleb, Stefan ;

Mueckl, Anton G. .

ORGANIC ELECTRONICS, 2001, 2 (01) :1-36

[7]

Cassinelli M. E., 1996, NIOSH MANUAL ANAL ME

[8]

Center S. A., 1995, TXB VET INTERNAL MED, P1287

[9] Evidence against a role for endotoxin in the hepatic encephalopathy of rats with thioacetamide-induced fulminant hepatic failure [J].

Chen, CT ;

Chu, CJ ;

Wang, TF ;

Lu, RH ;

Lee, FY ;

Chang, FY ;

Lin, HC ;

Chan, CC ;

Wang, SS ;

Huang, HC ;

Lee, SD .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2005, 20 (03) :450-455

[10] Quantitative analysis of ammonia on the breath of patients in end-stage renal failure [J].

Davies, S ;

Spanel, P ;

Smith, D .

KIDNEY INTERNATIONAL, 1997, 52 (01) :223-228

← 1 2 3 4 →