Drugging the gut microbiota: toward rational modulation of bacterial composition in the gut

被引：9

作者：

Altamura, Fernando ^{[1
]}

Maurice, Corinne F. ^{[2
]}

Castagner, Bastien ^{[1
]}

机构：

[1] McGill Univ, Dept Pharmacol & Therapeut, 3655 Prom Sir William Osler, Montreal, PQ H3G 1Y6, Canada

[2] McGill Univ, Dept Microbiol & Immunol, 3649 Prom Sir William Osler, Montreal, PQ H3G 0B1, Canada

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2020年 / 56卷

关键词：

Gut microbiota; Probiotics; Prebiotics; Gut health; Drug discovery; Bacterial metabolism; METABOLISM; PROBIOTICS; HEALTH; HOST; OBESITY; IMPACT; DIET;

D O I：

10.1016/j.cbpa.2019.09.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human gastrointestinal tract hosts almost a trillion microorganisms, organized in a complex community known as the gut microbiota, an integral part of human physiology and metabolism. Indeed, disease-specific alterations in the gut microbiota have been observed in several chronic disorders, including obesity and inflammatory bowel diseases. Correcting these alterations could revert the development of such pathologies or alleviate their symptoms. Recently, the gut microbiota has been the target of drug discovery that goes beyond classic probiotic approaches. This short review examines the promises and limitations of the latest strategies designed to modulate the gut bacterial community, and it explores the druggability of the gut microbiota by focusing on the potential of small molecules and prebiotics.

引用

页码：10 / 15

页数：6

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