Ascorbic acid preferentially enhances type I and III collagen gene transcription in human skin fibroblasts

被引：65

作者：

Tajima, S ^{[1
]}

Pinnell, SR ^{[1
]}

机构：

[1] DUKE UNIV,MED CTR,DIV DERMATOL,DURHAM,NC 27710

来源：

JOURNAL OF DERMATOLOGICAL SCIENCE | 1996年 / 11卷 / 03期

关键词：

collagen; ascorbic acid; gene transcription;

D O I：

10.1016/0923-1811(95)00640-0

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Ascorbic acid is a potent stimulator for type I and III collagen expressions in human skin fibroblasts; stimulation of type I and III collagen synthesis and their mRNA levels by ascorbic acid has been reported previously. Nuclear run-on experiments demonstrated that ascorbic acid enhanced the transcription of type I and III collagen genes 4- and 3.4-fold respectively, whereas transcription of type IV collagen was slightly stimulated (1.7-fold). The results suggest that ascorbic acid preferentially enhanced type I and III collagen gene transcription.

引用

收藏

页码：250 / 253

页数：4

相关论文

共 24 条

[1] STRUCTURE OF A CDNA FOR THE PRO-ALPHA2 CHAIN OF HUMAN TYPE-I PROCOLLAGEN - COMPARISON WITH CHICK CDNA FOR PROALPHA2(I) IDENTIFIES STRUCTURALLY CONSERVED FEATURES OF THE PROTEIN AND THE GENE [J].

BERNARD, MP ;

MYERS, JC ;

CHU, ML ;

RAMIREZ, F ;

EIKENBERRY, EF ;

PROCKOP, DJ .

BIOCHEMISTRY, 1983, 22 (05) :1139-1145

[2] NUCLEOTIDE-SEQUENCES OF COMPLEMENTARY DEOXYRIBONUCLEIC ACIDS FOR THE PRO-ALPHA-1 CHAIN OF HUMAN TYPE-I PROCOLLAGEN - STATISTICAL EVALUATION OF STRUCTURES THAT ARE CONSERVED DURING EVOLUTION [J].

BERNARD, MP ;

CHU, ML ;

MYERS, JC ;

RAMIREZ, F ;

EIKENBERRY, EF ;

PROCKOP, DJ .

BIOCHEMISTRY, 1983, 22 (22) :5213-5223

[3]

CHU ML, 1985, J BIOL CHEM, V260, P4357

[4]

DADDONA PE, 1984, J BIOL CHEM, V259, P2101

[5] ASCORBIC-ACID SPECIFICALLY INCREASES TYPE-I AND TYPE-III PROCOLLAGEN MESSENGER-RNA LEVELS IN HUMAN-SKIN FIBROBLASTS [J].

GEESIN, JC ;

DARR, D ;

KAUFMAN, R ;

MURAD, S ;

PINNELL, SR .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1988, 90 (04) :420-424

[6]

GOLDBERG GI, 1986, J BIOL CHEM, V261, P6600

[7] STIMULATION OF 3T3 CELLS INDUCES TRANSCRIPTION OF THE C-FOS PROTO-ONCOGENE [J].

GREENBERG, ME ;

ZIFF, EB .

NATURE, 1984, 311 (5985) :433-438

[8] ALTERNATIVE SPLICING OF HUMAN ELASTIN MESSENGER-RNA INDICATED BY SEQUENCE-ANALYSIS OF CLONED GENOMIC AND COMPLEMENTARY-DNA [J].

INDIK, Z ;

YEH, H ;

ORNSTEINGOLDSTEIN, N ;

SHEPPARD, P ;

ANDERSON, N ;

ROSENBLOOM, JC ;

PELTONEN, L ;

ROSENBLOOM, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (16) :5680-5684

[9] STUDIES ON THE UNDERHYDROXYLATED BASEMENT-MEMBRANE PROCOLLAGEN SYNTHESIZED BY RAT PARIETAL YOLK SACS IN THE PRESENCE OF ALPHA,ALPHA'-DIPYDRIDYL [J].

KARAKASHIAN, MW ;

KEFALIDES, NA .

CONNECTIVE TISSUE RESEARCH, 1982, 10 (3-4) :247-262

[10]

KURATA S, 1991, J BIOL CHEM, V266, P9997