A Novel Screening Biomarker in Gastric Cancer: Serum Dickkopf-1

被引：24

作者：

Gomceli, Ismail

Bostanci, Erdal B.

Ozer, Ilter

Kemik, Ahu S. ^{[1
]}

Turhan, Nesrin

Tez, Mesut ^{[3
]}

Kilic, Selim ^{[2
]}

Demiriz, Baris ^{[3
]}

Akoglu, Musa

机构：

[1] Istanbul Univ, Cerrahpasa Med Fac, Dept Biochem, Istanbul, Turkey

[2] Ankara Gulhane Mil Med Sch, Dept Epidemiol, Ankara, Turkey

[3] Ankara Numune Training & Res Hosp, Dept Gen Surg, Ankara, Turkey

来源：

HEPATO-GASTROENTEROLOGY | 2012年 / 59卷 / 117期

关键词：

Dickkopf-1; protein; Gastric cancer; Adenocarcinoma; ANTAGONIST; EPIDEMIOLOGY; PATHOGENESIS; PEPSINOGEN; MECHANISMS; TARGET;

D O I：

10.5754/hge11516

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background/Aims: Despite all the knowledge about gastric cancer, there is no prognostic biomarker which could be useful for early detection. Dickkopf-1 (DKK-1), a secreted protein, is known as a negative regulator of the Wnt signaling pathway DKK-1 is reported to be over expressed in many malignant tissues. The purpose of this study was to elucidate the normal level of serum DKK-1 (sDKK-1) levels in healthy Turkish peoples and to investigate the clinical utility of sDKK-1 levels for gastric cancer screening. Methodology: Serum DKK-1 levels were measured in 69 healthy controls and in 60 gastric adenocarcinoma patients with ELISA and sDKK-1 levels were compared with clinicopathological features and outcomes in gastric cancer patients. Results: Serum concentrations of DKK-1 in gastric adeno cancer patients were significantly higher than control patients (p<0.001). The optimal cut-off for sDKK-1 levels order to discriminate control group from gastric cancer patients was 25U/mL with sensitivity equal to 100% and specificity equal to 100%. Conclusions: Serum DKK-1 levels may be a potentially useful novel serologic marker for gastric cancers.

引用

页码：1661 / 1664

页数：4

共 25 条

[1]

Brenner Hermann, 2009, V472, P467, DOI 10.1007/978-1-60327-492-0_23

[2] Epidemiology of gastric cancer [J].