HER Targeting in HER2-Negative Breast Cancers: Looking for the HER3 Positive

被引:8
作者
Campbell, Marcia R. [1 ]
Moasser, Mark M. [1 ]
机构
[1] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA
关键词
GEMCITABINE; INHIBITORS; PATHWAY; ERBB3;
D O I
10.1158/1078-0432.CCR-14-3012
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Targeting HER2 for the treatment of HER2-positive breast cancers is now a validated treatment paradigm. However, evidence suggests that this family of receptors may have important roles outside of the realm of HER2 amplification. There is considerable interest in the development of biomarkers to identify such breast cancers. (C) 2015 AACR.
引用
收藏
页码:2886 / 2888
页数:3
相关论文
共 12 条
  • [1] ALIMANDI M, 1995, ONCOGENE, V10, P1813
  • [2] HER3 Comes of Age: New Insights into Its Functions and Role in Signaling, Tumor Biology, and Cancer Therapy
    Campbell, Marcia R.
    Amin, Dhara
    Moasser, Mark M.
    [J]. CLINICAL CANCER RESEARCH, 2010, 16 (05) : 1373 - 1383
  • [3] Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    Cunningham, D
    Humblet, Y
    Siena, S
    Khayat, D
    Bleiberg, H
    Santoro, A
    Bets, D
    Mueser, M
    Harstrick, A
    Verslype, C
    Chau, I
    Van Cutsem, E
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (04) : 337 - 345
  • [4] MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    Engelman, Jeffrey A.
    Zejnullahu, Kreshnik
    Mitsudomi, Tetsuya
    Song, Youngchul
    Hyland, Courtney
    Park, Joon Oh
    Lindeman, Neal
    Gale, Christopher-Michael
    Zhao, Xiaojun
    Christensen, James
    Kosaka, Takayuki
    Holmes, Alison J.
    Rogers, Andrew M.
    Cappuzzo, Federico
    Mok, Tony
    Lee, Charles
    Johnson, Bruce E.
    Cantley, Lewis C.
    Janne, Pasi A.
    [J]. SCIENCE, 2007, 316 (5827) : 1039 - 1043
  • [5] Molecular Pathways: PI3K Pathway Targets in Triple-Negative Breast Cancers
    Gordon, Vallerie
    Banerji, Shantanu
    [J]. CLINICAL CANCER RESEARCH, 2013, 19 (14) : 3738 - 3744
  • [6] Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3
    Jura, Natalia
    Shan, Yibing
    Cao, Xiaoxian
    Shaw, David E.
    Kuriyan, John
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (51) : 21608 - 21613
  • [7] Antiproliferative Effect of Lapatinib in HER2-Positive and HER2-Negative/HER3-High Breast Cancer: Results of the Presurgical Randomized MAPLE Trial (CRUK E/06/039)
    Leary, Alexandra
    Evans, Abigail
    Johnston, Stephen R. D.
    A'Hern, Roger
    Bliss, Judith M.
    Sahoo, Rashmita
    Detre, Simone
    Haynes, Benjamin P.
    Hills, Margaret
    Harper-Wynne, Catherine
    Bundred, Nigel
    Coombes, Gill
    Smith, Ian
    Dowsett, Mitch
    [J]. CLINICAL CANCER RESEARCH, 2015, 21 (13) : 2932 - 2940
  • [8] Clinical Activity of Gemcitabine Plus Pertuzumab in Platinum-Resistant Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer
    Makhija, Sharmila
    Amler, Lukas C.
    Glenn, Dana
    Ueland, Frederick R.
    Gold, Michael A.
    Dizon, Don S.
    Paton, Virginia
    Lin, Chin-Yu
    Januario, Thomas
    Ng, Kimmie
    Strauss, Andreas
    Kelsey, Stephen
    Sliwkowski, Mark X.
    Matulonis, Ursula
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (07) : 1215 - 1223
  • [9] Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada clinical trials group
    Moore, Malcolm J.
    Goldstein, David
    Hamm, John
    Figer, Arie
    Hecht, Joel R.
    Gallinger, Steven
    Au, Heather J.
    Murawa, Pawel
    Walde, David
    Wolff, Robert A.
    Campos, Daniel
    Lim, Robert
    Ding, Keyue
    Clark, Gary
    Voskoglou-Nomikos, Theodora
    Ptasynski, Mieke
    Parulekar, Wendy
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (15) : 1960 - 1966
  • [10] HER2 status and benefit from adjuvant trastuzumab in breast cancer
    Paik, Soonmyung
    Kim, Chungyeul
    Wolmark, Norman
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (13) : 1409 - 1411