GSK3 modulation in acute lung injury, myocarditis and polycystic kidney disease-related aneurysm

被引：9
作者：
Liu, Wei-Lun [1 ,2 ,3 ]
Chiang, Fu-Tien [4 ,5 ]
Kao, Juliana Tze-Wah [6 ,7 ]
Chiou, Shih-Hwa [8 ,9 ,10 ]
Lin, Heng-Liang [3 ,11 ]
机构：
[1] Fu Jen Catholic Univ, Coll Med, Sch Med, New Taipei, Taiwan
[2] Fu Jen Catholic Univ, Fu Jen Catholic Univ Hosp, Dept Emergency & Crit Care Med, Div Crit Care Med, New Taipei, Taiwan
[3] Fu Jen Catholic Univ, Fu Jen Catholic Univ Hosp, Ctr Innovat, New Taipei, Taiwan
[4] Fu Jen Catholic Univ, Fu Jen Catholic Univ Hosp, Dept Internal Med, New Taipei, Taiwan
[5] Natl Taiwan Univ, Dept Internal Med, Div Cardiol, Coll Med & Hosp, Taipei, Taiwan
[6] Fu Jen Catholic Univ, Fu Jen Catholic Univ Hosp, Dept Internal Med, Div Nephrol, New Taipei, Taiwan
[7] Natl Taiwan Univ Hosp, Dept Internal Med, Div Nephrol, Taipei, Taiwan
[8] Taipei Vet Gen Hosp, Dept Med Res, Taipei, Taiwan
[9] Natl Yang Ming Univ, Inst Pharmacol, Taipei, Taiwan
[10] Acad Sinica, Gen Res Ctr, Taipei, Taiwan
[11] Fu Jen Catholic Univ, Fu Jen Catholic Univ Hosp, Div Fund Managing, New Taipei, Taiwan
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2020年 / 1867卷 / 11期
关键词：
PI3K/Akt/GSK3; beta/MCP-1; axis; M1/M2; macrophages; Pulmonary edema; HMGB1/IL-17A/autophagy; Podocyte; Mitotic catastrophe; GLYCOGEN-SYNTHASE KINASE-3; NF-KAPPA-B; P-GLYCOPROTEIN EXPRESSION; GROUP BOX 1; SIGNALING PATHWAY; MACROPHAGE-MIGRATION; ACUTE-PANCREATITIS; LITHIUM TREATMENT; CARDIOMYOCYTE APOPTOSIS; STIMULATED MACROPHAGES;
D O I：
10.1016/j.bbamcr.2020.118798
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
GSK3 are involved in different physical and pathological conditions and inflammatory regulated by macrophages contribute to significant mechanism. Infection stimuli may modulate GSK3 activity and influence host cell adaption, immune cells infiltration or cytokine expressions. To further address the role of GSK3 modulation in macrophages, the signal transduction of three major organs challenged by endotoxin, virus and genetic inherited factors are briefly introduced (lung injury, myocarditis and autosomal dominant polycystic kidney disease). As a result of pro-inflammatory and anti-inflammatory functions of GSK3 in different microenvironments and stages of macrophages (M1/M2), the rational resolution should be considered by adequately GSK3.
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页数：12
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