Methods to assess sensitivity of optical coherence tomography systems

被引:43
作者
Agrawal, Anant [1 ]
Pfefer, T. Joshua [1 ]
Woolliams, Peter D. [2 ]
Tomlins, Peter H. [3 ]
Nehmetallah, George [4 ]
机构
[1] US FDA, Ctr Devices & Radiol Hlth, Silver Spring, MD USA
[2] Natl Phys Lab, Funct Mat Grp, Teddington, Middx, England
[3] Queen Mary Univ London, Barts & London Sch Med & Dent, London E1 1BB, England
[4] Catholic Univ Amer, Dept Elect & Comp Sci, Washington, DC 20064 USA
来源
BIOMEDICAL OPTICS EXPRESS | 2017年 / 8卷 / 02期
关键词
SWEPT-SOURCE; PERFORMANCE; LASER; DEPTH;
D O I
10.1364/BOE.8.000902
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Measuring the sensitivity of an optical coherence tomography (OCT) system determines the minimum sample reflectivity it can detect and provides a figure of merit for system optimization and comparison. The published literature lacks a detailed description of OCT sensitivity measurement procedures. Here we describe a commonly-used measurement method and introduce two new phantom-based methods, which also offer a means to directly visualize low reflectivity conditions relevant to biological tissue. We provide quantitative results for the three methods from different OCT system configurations and discuss the methods' advantages and disadvantages. (C) 2017 Optical Society of America
引用
收藏
页码:902 / 917
页数:16
相关论文
共 25 条
  • [1] Regulatory perspectives and research activities at the FDA on the use of phantoms with in vivo diagnostic devices
    Agrawal, Anant
    Gavrielides, Marios A.
    Weininger, Sandy
    Chakrabarti, Kish
    Pfefer, Joshua
    [J]. DESIGN AND PERFORMANCE VALIDATION OF PHANTOMS USED IN CONJUNCTION WITH OPTICAL MEASUREMENTS OF TISSUE, 2008, 6870
  • [2] Quantitative evaluation of optical coherence tomography signal enhancement with gold nanoshells
    Agrawal, Anant
    Huang, Stanley
    Lin, Alex Wei Haw
    Lee, Min-Ho
    Barton, Jennifer K.
    Drezek, Rebekah A.
    Pfefer, T. Joshua
    [J]. JOURNAL OF BIOMEDICAL OPTICS, 2006, 11 (04)
  • [3] [Anonymous], Refractive index database
  • [4] Brezinski M.E., 2006, OPTICAL COHERENCE TO
  • [5] Swept source optical coherence tomography using an all-fiber 1300-nm ring laser source
    Choma, MA
    Hsu, K
    Izatt, JA
    [J]. JOURNAL OF BIOMEDICAL OPTICS, 2005, 10 (04)
  • [6] Sensitivity advantage of swept source and Fourier domain optical coherence tomography
    Choma, MA
    Sarunic, MV
    Yang, CH
    Izatt, JA
    [J]. OPTICS EXPRESS, 2003, 11 (18): : 2183 - 2189
  • [7] Performance of reduced bit-depth acquisition for optical frequency domain imaging
    Goldberg, Brian D.
    Vakoc, Benjamin J.
    Oh, Wang-Yuhl
    Suter, Melissa J.
    Waxman, Sergio
    Freilich, Mark I.
    Bouma, Brett E.
    Tearney, Guillermo J.
    [J]. OPTICS EXPRESS, 2009, 17 (19): : 16957 - 16968
  • [8] Longitudinal vascular dynamics following cranial window and electrode implantation measured with speckle variance optical coherence angiography
    Hammer, Daniel X.
    Lozzi, Andrea
    Abliz, Erkinay
    Greenbaum, Noah
    Agrawal, Anant
    Krauthamer, Victor
    Welle, Cristin G.
    [J]. BIOMEDICAL OPTICS EXPRESS, 2014, 5 (08): : 2823 - 2836
  • [9] Multimodal adaptive optics retinal imager: design and performance
    Hammer, Daniel X.
    Ferguson, R. Daniel
    Mujat, Mircea
    Patel, Ankit
    Plumb, Emily
    Iftimia, Nicusor
    Chui, Toco Y. P.
    Akula, James D.
    Fulton, Anne B.
    [J]. JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, 2012, 29 (12) : 2598 - 2607
  • [10] Role of beat noise in limiting the sensitivity of optical coherence tomography
    Haskell, Richard C.
    Liao, David
    Pivonka, Adam E.
    Bell, Tera L.
    Haberle, Brendan R.
    Hoeling, Barbara M.
    Petersen, Daniel C.
    [J]. JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, 2006, 23 (11) : 2747 - 2755