Biomarker-Driven Therapeutic Management of Alzheimer's Disease: Establishing the Foundations

被引：16

作者：

Cummings, J. ^{[1
]}

Zhong, K. ^{[1
]}

机构：

[1] Cleveland Clin, Lou Ruvo Ctr Brain Hlth, Las Vegas, NV 89106 USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2014年 / 95卷 / 01期

关键词：

MILD COGNITIVE IMPAIRMENT; CORTICAL ACETYLCHOLINESTERASE ACTIVITY; NATIONAL INSTITUTE; CLINICAL-TRIALS; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; DRUG DISCOVERY; CEREBROSPINAL-FLUID; AMYLOID-BETA(1-42) BIOMARKER; IMAGING ABNORMALITIES;

D O I：

10.1038/clpt.2013.205

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Biomarkers are characteristics that are objectively measured and evaluated as indicators of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention. Amyloid measures become abnormal early in the Alzheimer's disease process and have only weak correlations with disease progression and cognitive decline; cerebrospinal fluid tau, brain atrophy, and reduced cortical metabolism correlate with cognitive measures and disease progression. Combinations of biomarkers have higher correlations and are better predictors of future decline than single biomarkers. Current biomarkers do not account for all of the variance in Alzheimer's disease; a more complete repertoire of biomarkers that more comprehensively assay the disease process is needed.

引用

页码：67 / 77

页数：11

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