Chromatin's thread to alternative splicing regulation

被引：37
作者：
Iannone, Camilla [1 ,2 ]
Valcarcel, Juan [1 ,2 ,3 ]
机构：
[1] CRG, Barcelona, Spain
[2] Univ Pompeu Fabra, Barcelona, Spain
[3] Inst Catalana Recerca & Estudis Avancats, Barcelona 08003, Spain
来源：
CHROMOSOMA | 2013年 / 122卷 / 06期
关键词：
DNA-METHYLATION; TRANSCRIPTION ELONGATION; DESIGN PRINCIPLES; SR PROTEINS; NASCENT RNA; SPLICEOSOME; RECRUITMENT; EXONS; ORGANIZATION; ARCHITECTURE;
D O I：
10.1007/s00412-013-0425-x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Intron removal (pre-mRNA splicing) is a necessary step for expression of most genes in higher eukaryotes. Alternative splice site selection is a prevalent mechanism that diversifies genome outputs and offers ample opportunities for gene regulation in these organisms. Pre-mRNA splicing occurs co-transcriptionally and is influenced by features in chromatin structure, including nucleosome density and epigenetic modifications. We review here the molecular mechanisms by which the reciprocal interplay between chromatin and RNA processing can contribute to alternative splicing regulation.
引用
收藏
页码：465 / 474
页数：10
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