Antidepressants for neuro-regeneration: from depression to Alzheimer's disease

被引：28
作者：
Kim, Hyun-Jung [1 ]
Kim, Woosuk [1 ]
Kong, Sun-Young [1 ]
机构：
[1] Chung Ang Univ, Coll Pharm, Lab Mol & Stem Cell Pharmacol, Seoul 156756, South Korea
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2013年 / 36卷 / 11期
基金：
新加坡国家研究基金会;
关键词：
Antidepressants; Neurogenesis; Alzheimer's disease; Brain derived neurotrophic factor; Depression; LIPOPOLYSACCHARIDE-INDUCED APOPTOSIS; CHRONIC FLUOXETINE TREATMENT; NEUROTROPHIC FACTOR BDNF; HIPPOCAMPAL NEUROGENESIS; DOUBLE-BLIND; CELL-PROLIFERATION; STEM-CELLS; POSTSTROKE DEPRESSION; PARKINSONS-DISEASE; HUNTINGTONS-DISEASE;
D O I：
10.1007/s12272-013-0238-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Recently identified new potential functions of antidepressants in the treatment of neurodegenerative will be introduced. Antidepressants are reported to regulate stem cell fate to regenerate neurons in the adult hippocampus and are effective in reducing toxic amyloid peptides and are known to increase neurotrophic factor such as brain-derived neurotrophic factor. Clinical trial data support that antidepressants have potential to treat Alzheimer's disease.
引用
收藏
页码：1279 / 1290
页数：12
相关论文
共 139 条
[1]   Depression in Parkinson's disease - Must be properly diagnosis and treated to avoid serious morbidity [J].
Allain, H ;
Schuck, S ;
Mauduit, N .
BRITISH MEDICAL JOURNAL, 2000, 320 (7245) :1287-1288
[2]   AUTORADIOGRAPHIC AND HISTOLOGICAL EVIDENCE OF POSTNATAL HIPPOCAMPAL NEUROGENESIS IN RATS [J].
ALTMAN, J ;
DAS, GD .
JOURNAL OF COMPARATIVE NEUROLOGY, 1965, 124 (03) :319-&
[3]   Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor [J].
Anacker, C. ;
Zunszain, P. A. ;
Cattaneo, A. ;
Carvalho, L. A. ;
Garabedian, M. J. ;
Thuret, S. ;
Price, J. ;
Pariante, C. M. .
MOLECULAR PSYCHIATRY, 2011, 16 (07) :738-750
[4]   A review on cholinesterase inhibitors for Alzheimer's disease [J].
Anand, Preet ;
Singh, Baldev .
ARCHIVES OF PHARMACAL RESEARCH, 2013, 36 (04) :375-399
[5]   Randomized study of sertraline and low-dose amitriptyline in patients with Parkinson's disease and depression: Effect on quality of life [J].
Antonini, Angelo ;
Tesei, Silvana ;
Zecchinelli, Anna ;
Barone, Paolo ;
De Gaspari, Danilo ;
Canesi, Margherita ;
Sacilotto, Giorgio ;
Meucci, Nicoletta ;
Mariani, Claudio ;
Pezzoli, Gianni .
MOVEMENT DISORDERS, 2006, 21 (08) :1119-1122
[6]  
Arlt S, 2013, CURR ALZHEIMER RES, V10, P72
[7]   Alzheimer's disease [J].
Ballard, Clive ;
Gauthier, Serge ;
Corbett, Anne ;
Brayne, Carol ;
Aarsland, Dag ;
Jones, Emma .
LANCET, 2011, 377 (9770) :1019-1031
[8]   Agomelatine, a new antidepressant, induces regional changes in hippocampal neurogenesis [J].
Banasr, Mounira ;
Soumier, Amelie ;
Hery, Micheline ;
Mocaer, Elisabeth ;
Daszuta, Annie .
BIOLOGICAL PSYCHIATRY, 2006, 59 (11) :1087-1096
[9]   Moclobemide treatment in multiple sclerosis patients with comorbid depression: An open-label safety trial [J].
Barak, Y ;
Ur, E ;
Achiron, A .
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES, 1999, 11 (02) :271-273
[10]   Fluvoxamine treatment of major depression associated with multiple sclerosis [J].
Benedetti, F ;
Campori, E ;
Colombo, C ;
Smeraldi, E .
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES, 2004, 16 (03) :364-366
12345678910