Cognition and Amyloid Load in Alzheimer Disease Imaged With Florbetapir F 18 (AV-45) Positron Emission Tomography

被引:37
作者
Rosenberg, Paul B. [1 ]
Wong, D. F. [1 ,2 ,3 ,4 ]
Edell, S. L. [5 ]
Ross, J. S. [6 ]
Joshi, A. D. [7 ]
Brasic, J. R. [2 ]
Zhou, Y. [2 ]
Raymont, V. [2 ]
Kumar, A. [2 ]
Ravert, H. T. [2 ]
Dannals, R. F. [2 ]
Pontecorvo, M. J. [7 ]
Skovronsky, D. M. [7 ,8 ]
Lyketsos, C. G. [1 ]
机构
[1] Johns Hopkins Med Inst, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA
[2] Johns Hopkins Med Inst, Dept Radiol & Radiol Sci, Baltimore, MD 21205 USA
[3] Johns Hopkins Med Inst, Dept Neurosci, Baltimore, MD 21205 USA
[4] Johns Hopkins Med Inst, Dept Environm Hlth Sci, Baltimore, MD 21205 USA
[5] Community Hlth Res, North East, MD USA
[6] Memory Enhancement Ctr, Eatontown, NJ USA
[7] Avid Radiopharmaceut Inc, Philadelphia, PA USA
[8] Univ Penn, Philadelphia, PA 19104 USA
关键词
Alzheimer; amyloid; cognition; 18-flourine; PET tracer; positron emission tomography; standardized uptake value ratios; PITTSBURGH COMPOUND-B; DEPOSITION; MEMORY; INDIVIDUALS; DECLINE;
D O I
10.1016/j.jagp.2012.11.016
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Objective: To examine the association between regional brain uptake of a novel amyloid positron emission tomography (PET) tracer florbetapir F 18 ([F-18]-AV-45) and cognitive performance in a pilot study. Design: Cross-sectional comparison of [F-18]-AV-45 in AD patients versus controls. Setting: Three specialty memory clinics. Participants: Eleven participants with probable Alzheimer disease (AD) by NINDS/ADRDA criteria and 15 healthy comparison (HC) participants. Measurements: Participants underwent PET imaging following a 370 MBq (10 mCi) intravenous administration of [F-18]-AV-45. Regional/cerebellar standardized uptake value ratios (SUVRs) were calculated. Cognition was assessed using Mini-Mental State Examination, Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog), Wechsler Logical Memory IA (immediate recall) test (LMIA), and verbal category fluency. Results: Greater [F-18]-AV-45 SUVR was associated with poorer performance on all cognitive tests. In the HC group, occipital, parietal, precuneus, temporal, and cortical average SUVR was associated with greater ADAS-Cog, and greater anterior cingulate SUVR was associated with lower LMIA. Two HC participants had [F-18]-AV-45 cortical/cerebellar SUVR greater than 1.5, one of whom had deficits in episodic recall and on follow-up met criteria for amnestic mild cognitive impairment. Conclusion: [F-18]-AV-45 SUVR in several brain regions was associated with worse global cognitive performance particularly in HC, suggesting its potential as a marker of preclinical AD.
引用
收藏
页码:272 / 278
页数:7
相关论文
共 50 条
  • [31] 18F-florbetapir Positron Emission Tomography-determined Cerebral -Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery
    Klinger, Rebecca Y.
    James, Olga G.
    Borges-Neto, Salvador
    Bisanar, Tiffany
    Li, Yi-Ju
    Qi, Wenjing
    Berger, Miles
    Terrando, Niccolo
    Newman, Mark F.
    Doraiswamy, P. Murali
    Mathew, Joseph P.
    ANESTHESIOLOGY, 2018, 128 (04) : 728 - 744
  • [32] Amyloid and Tau Positron Emission Tomography Imaging in Alzheimer's Disease and Other Tauopathies
    Maschio, Cinzia
    Ni, Ruiqing
    FRONTIERS IN AGING NEUROSCIENCE, 2022, 14
  • [33] The image quality, amyloid-β detectability, and acquisition time of clinical florbetapir positron emission tomography in Alzheimer's disease and healthy adults
    Xie, Hongsheng
    Li, Yuhao
    Wu, Xiaoai
    Wang, Ruihan
    Long, Xipeng
    Su, Minggang
    Chen, Qin
    Li, Lin
    Tian, Rong
    Jia, Zhiyun
    QUANTITATIVE IMAGING IN MEDICINE AND SURGERY, 2023, 13 (12) : 7765 - 7776
  • [34] Imaging cardiac amyloidosis: a pilot study using 18F-florbetapir positron emission tomography
    Dorbala, Sharmila
    Vangala, Divya
    Semer, James
    Strader, Christopher
    Bruyere, John R., Jr.
    Di Carli, Marcelo F.
    Moore, Stephen C.
    Falk, Rodney H.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2014, 41 (09) : 1652 - 1662
  • [35] Comparison of imaging biomarkers for Alzheimer's disease: amyloid imaging with [18F]florbetapir positron emission tomography and magnetic resonance imaging voxel-based analysis for entorhinal cortex atrophy
    Tateno, Amane
    Sakayori, Takeshi
    Kawashima, Yoshitaka
    Higuchi, Makoto
    Suhara, Tetsuya
    Mizumura, Sunao
    Mintun, Mark A.
    Skovronsky, Daniel M.
    Honjo, Kazuyoshi
    Ishihara, Keiichi
    Kumita, Shinichiro
    Suzuki, Hidenori
    Okubo, Yoshiro
    INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 2015, 30 (05) : 505 - 513
  • [36] Imaging cardiac amyloidosis: a pilot study using 18F-florbetapir positron emission tomography
    Sharmila Dorbala
    Divya Vangala
    James Semer
    Christopher Strader
    John R. Bruyere
    Marcelo F. Di Carli
    Stephen C. Moore
    Rodney H Falk
    European Journal of Nuclear Medicine and Molecular Imaging, 2014, 41 : 1652 - 1662
  • [37] Comparison of Visual and Quantitative Florbetapir F 18 Positron Emission Tomography Analysis in Predicting Mild Cognitive Impairment Outcomes
    Schreiber, Stefanie
    Landau, Susan M.
    Fero, Allison
    Schreiber, Frank
    Jagust, William J.
    JAMA NEUROLOGY, 2015, 72 (10) : 1183 - 1190
  • [38] Imaging Aβ and tau in early stage Alzheimer's disease with [18F]AV45 and [18F]AV1451
    Firouzian, Azadeh
    Whittington, Alex
    Searle, Graham E.
    Koychev, Ivan
    Zamboni, Giovanna
    Lovestone, Simon
    Gunn, Roger N.
    EJNMMI RESEARCH, 2018, 8
  • [39] A 18F-Labeled BF-227 Derivative as a Potential Radioligand for Imaging Dense Amyloid Plaques by Positron Emission Tomography
    Furumoto, Shozo
    Okamura, Nobuyuki
    Furukawa, Katsutoshi
    Tashiro, Manabu
    Ishikawa, Yoichi
    Sugi, Kentaro
    Tomita, Naoki
    Waragai, Masaaki
    Harada, Ryuichi
    Tago, Tetsuro
    Iwata, Ren
    Yanai, Kazuhiko
    Arai, Hiroyuki
    Kudo, Yukitsuka
    MOLECULAR IMAGING AND BIOLOGY, 2013, 15 (04) : 497 - 506
  • [40] Beta-amyloid deposition and cognitive function in patients with major depressive disorder with different subtypes of mild cognitive impairment: 18F-florbetapir (AV-45/Amyvid) PET study
    Kuan-Yi Wu
    Chia-Yih Liu
    Cheng-Sheng Chen
    Chia-Hsiang Chen
    Ing-Tsung Hsiao
    Chia-Ju Hsieh
    Chin-Pang Lee
    Tzu-Chen Yen
    Kun-Ju Lin
    European Journal of Nuclear Medicine and Molecular Imaging, 2016, 43 : 1067 - 1076