One-pot three-component Mannich reaction catalyzed by 2-hydroxylpyridine

被引：7
作者：
Jin Li-li [1 ]
Lei Yun-tao [1 ]
机构：
[1] China Pharmaceut Univ, Coll Sci, Nanjing 210009, Jiangsu, Peoples R China
来源：
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2013年 / 29卷 / 04期
关键词：
2-Hydroxylpyridine; Catalyze; Mannich reaction; beta-Amino carbonyl compound; IONIC LIQUID; CHLORIDE; ACID;
D O I：
10.1007/s40242-013-2362-x
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An effcient synthetic protocol for the beta-amino carbonyl compounds was developed via one-pot three-component Mannich reaction of aromatic aldehydes, aromatic amines and cyclohexanone catalyzed by 2-hydroxylpyridine under mild reaction conditions. beta-Amino carbonyl compounds were obtained in moderate to good yields and reasonable diastereoselectivities. The effects of different solvents, catalyst amounts and the scope of different substrates on the Mannich reactions were investigated. The plausible reaction mechanism was also discussed.
引用
收藏
页码：710 / 713
页数：4
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