Rhodium(I)-Catalyzed Cycloisomerization of Nitrogen-Tethered Indoles and Alkylidenecyclopropanes: Convenient Access to Polycyclic Indole Derivatives

被引：31

作者：

Zhang, Di-Han ^{[1
]}

Tang, Xiang-Ying ^{[1
]}

Wei, Yin ^{[1
]}

Shi, Min ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 41期

基金：

中国国家自然科学基金;

关键词：

alkylidenecyclopropanes; cycloisomerization; indoles; polycyclic indoles; rhodium; tetrahydrocarbolines; 3+2 INTRAMOLECULAR CYCLOADDITION; RING ENLARGEMENT; METHYLENECYCLOPROPANES; ALKALOIDS; ALK-5-YNYLIDENECYCLOPROPANES; ALKENYLIDENECYCLOPROPANES; HYDROAMINATION; CONSTRUCTION; CHEMISTRY; ALKYNES;

D O I：

10.1002/chem.201302331

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

At the end of its tether: A new synthetic protocol for the preparation of polycyclic indole derivatives has been developed from a rhodium(I)-catalyzed cycloisomerization of a nitrogen-tethered indole and alkylidenecyclopropane, affording the corresponding tetrahydro-β-carboline derivatives in moderate to good yields (see scheme). Further transformations give a direct and rapid route to tetracyclic compounds through transition-metal catalysis. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：13668 / 13673

页数：6

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