共 49 条
Challenges in pharmacogenetics
被引:8
作者:

Cascorbi, Ingolf
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h-index: 0
机构:
Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany

Bruhn, Oliver
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机构:
Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany

Werk, Anneke N.
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h-index: 0
机构:
Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany
机构:
[1] Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany
关键词:
CYP2C19;
GENOTYPE;
CYP2D6;
POLYMORPHISM;
ASSOCIATION;
CLOPIDOGREL;
METABOLISM;
IMPACT;
RISK;
PHARMACOKINETICS;
HYDROXYLATION;
D O I:
10.1007/s00228-013-1492-x
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
The attempt to optimize drug treatment of patients by using evidenced-based medicine considering individual physiological and disease-related conditions is standard of modern medicine. Pharmacogenetics (PGx) has contributed to individualization considering hereditary genetic information; however, increasingly, pharmacogenomics is becoming essential, particularly in relation to modern oncology. New technologies such as next-generation sequencing and rapid development of computational and information sciences will help to better elucidate the consequences of genetic variation, considering also epigenetics and gene-environmental interactions and their translation into clinically relevant individual phenotypes. This review highlights the current challenging and most promising examples of PGx.
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收藏
页码:S17 / S23
页数:7
相关论文
共 49 条
[41]
Pharmacogenetics of opioids
[J].
Somogyi, Andrew A.
;
Barratt, Daniel T.
;
Coller, Janet K.
.
CLINICAL PHARMACOLOGY & THERAPEUTICS,
2007, 81 (03)
:429-444

Somogyi, Andrew A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Adelaide, Sch Med Sci, Discipline Pharmacol, Adelaide, SA 5005, Australia Univ Adelaide, Sch Med Sci, Discipline Pharmacol, Adelaide, SA 5005, Australia

Barratt, Daniel T.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Adelaide, Sch Med Sci, Discipline Pharmacol, Adelaide, SA 5005, Australia Univ Adelaide, Sch Med Sci, Discipline Pharmacol, Adelaide, SA 5005, Australia

Coller, Janet K.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Adelaide, Sch Med Sci, Discipline Pharmacol, Adelaide, SA 5005, Australia Univ Adelaide, Sch Med Sci, Discipline Pharmacol, Adelaide, SA 5005, Australia
[42]
Genetic variability of drug-metabolizing enzymes: the dual impact on psychiatric therapy and regulation of brain function
[J].
Stingl, J. C.
;
Brockmoeller, J.
;
Viviani, R.
.
MOLECULAR PSYCHIATRY,
2013, 18 (03)
:273-287

Stingl, J. C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Ulm, Inst Pharmacol Nat Prod & Clin Pharmacol, D-89069 Ulm, Germany Univ Ulm, Inst Pharmacol Nat Prod & Clin Pharmacol, D-89069 Ulm, Germany

Brockmoeller, J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Gottingen, Univ Med Ctr, Dept Clin Pharmacol, D-37073 Gottingen, Germany Univ Ulm, Inst Pharmacol Nat Prod & Clin Pharmacol, D-89069 Ulm, Germany

Viviani, R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Ulm, Dept Psychiat & Psychotherapy 3, D-89069 Ulm, Germany Univ Ulm, Inst Pharmacol Nat Prod & Clin Pharmacol, D-89069 Ulm, Germany
[43]
The cancer genome
[J].
Stratton, Michael R.
;
Campbell, Peter J.
;
Futreal, P. Andrew
.
NATURE,
2009, 458 (7239)
:719-724

Stratton, Michael R.
论文数: 0 引用数: 0
h-index: 0
机构:
Wellcome Trust Sanger Inst, Canc Genome Project, Cambridge CB10 1SA, England
Inst Canc Res, Sutton SM2 5NG, Surrey, England Wellcome Trust Sanger Inst, Canc Genome Project, Cambridge CB10 1SA, England

Campbell, Peter J.
论文数: 0 引用数: 0
h-index: 0
机构:
Wellcome Trust Sanger Inst, Canc Genome Project, Cambridge CB10 1SA, England
Univ Cambridge, Dept Haematol, Cambridge CB2 2XY, England Wellcome Trust Sanger Inst, Canc Genome Project, Cambridge CB10 1SA, England

Futreal, P. Andrew
论文数: 0 引用数: 0
h-index: 0
机构:
Wellcome Trust Sanger Inst, Canc Genome Project, Cambridge CB10 1SA, England Wellcome Trust Sanger Inst, Canc Genome Project, Cambridge CB10 1SA, England
[44]
Thiopurine treatment in inflammatory bowel disease - Clinical pharmacology and implication of pharmacogenetically guided dosing
[J].
Teml, Alexander
;
Schaeffeler, Elke
;
Herrlinger, Klaus R.
;
Klotz, Ulrich
;
Schwab, Matthias
.
CLINICAL PHARMACOKINETICS,
2007, 46 (03)
:187-208

Teml, Alexander
论文数: 0 引用数: 0
h-index: 0
机构: Dr Margarete Fischer Bosch Inst Clin Pharmacol, D-70376 Stuttgart, Germany

Schaeffeler, Elke
论文数: 0 引用数: 0
h-index: 0
机构: Dr Margarete Fischer Bosch Inst Clin Pharmacol, D-70376 Stuttgart, Germany

Herrlinger, Klaus R.
论文数: 0 引用数: 0
h-index: 0
机构: Dr Margarete Fischer Bosch Inst Clin Pharmacol, D-70376 Stuttgart, Germany

Klotz, Ulrich
论文数: 0 引用数: 0
h-index: 0
机构: Dr Margarete Fischer Bosch Inst Clin Pharmacol, D-70376 Stuttgart, Germany

Schwab, Matthias
论文数: 0 引用数: 0
h-index: 0
机构: Dr Margarete Fischer Bosch Inst Clin Pharmacol, D-70376 Stuttgart, Germany
[45]
Paraoxonase-1 Q192R Polymorphism and Antiplatelet Effects of Clopidogrel in Patients Undergoing Elective Coronary Stent Placement
[J].
Trenk, Dietmar
;
Hochholzer, Willibald
;
Fromm, Martin F.
;
Zolk, Oliver
;
Valina, Christian M.
;
Stratz, Christian
;
Neumann, Franz-Josef
.
CIRCULATION-CARDIOVASCULAR GENETICS,
2011, 4 (04)
:429-436

Trenk, Dietmar
论文数: 0 引用数: 0
h-index: 0
机构:
Herz Zentrum Bad Krozingen, D-79189 Bad Krozingen, Germany Herz Zentrum Bad Krozingen, D-79189 Bad Krozingen, Germany

Hochholzer, Willibald
论文数: 0 引用数: 0
h-index: 0
机构:
Herz Zentrum Bad Krozingen, D-79189 Bad Krozingen, Germany Herz Zentrum Bad Krozingen, D-79189 Bad Krozingen, Germany

Fromm, Martin F.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Erlangen Nurnberg, Inst Expt & Clin Pharmacol & Toxicol, Erlangen, Germany Herz Zentrum Bad Krozingen, D-79189 Bad Krozingen, Germany

Zolk, Oliver
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Erlangen Nurnberg, Inst Expt & Clin Pharmacol & Toxicol, Erlangen, Germany Herz Zentrum Bad Krozingen, D-79189 Bad Krozingen, Germany

Valina, Christian M.
论文数: 0 引用数: 0
h-index: 0
机构:
Herz Zentrum Bad Krozingen, D-79189 Bad Krozingen, Germany Herz Zentrum Bad Krozingen, D-79189 Bad Krozingen, Germany

Stratz, Christian
论文数: 0 引用数: 0
h-index: 0
机构:
Herz Zentrum Bad Krozingen, D-79189 Bad Krozingen, Germany Herz Zentrum Bad Krozingen, D-79189 Bad Krozingen, Germany

Neumann, Franz-Josef
论文数: 0 引用数: 0
h-index: 0
机构:
Herz Zentrum Bad Krozingen, D-79189 Bad Krozingen, Germany Herz Zentrum Bad Krozingen, D-79189 Bad Krozingen, Germany
[46]
Multiple personal genomes await
[J].
Venter, J. Craig
.
NATURE,
2010, 464 (7289)
:676-677

Venter, J. Craig
论文数: 0 引用数: 0
h-index: 0
机构:
J Craig Venter Inst, La Jolla, CA 92121 USA J Craig Venter Inst, La Jolla, CA 92121 USA
[47]
Association of sirolimus adverse effects with m-TOR, p70S6K or Raptor polymorphisms in kidney transplant recipients
[J].
Woillard, Jean-Baptiste
;
Kamar, Nassim
;
Rousseau, Annick
;
Rostaing, Lionel
;
Marquet, Pierre
;
Picard, Nicolas
.
PHARMACOGENETICS AND GENOMICS,
2012, 22 (10)
:725-732

Woillard, Jean-Baptiste
论文数: 0 引用数: 0
h-index: 0
机构:
Fac Med Limoges, INSERM, UMR S850, F-87025 Limoges, France
Univ Limoges, Limoges, France
CHU Limoges, Dept Pharmacol & Toxicol, Limoges, France Fac Med Limoges, INSERM, UMR S850, F-87025 Limoges, France

论文数: 引用数:
h-index:
机构:

Rousseau, Annick
论文数: 0 引用数: 0
h-index: 0
机构:
Fac Med Limoges, INSERM, UMR S850, F-87025 Limoges, France
Univ Limoges, Limoges, France Fac Med Limoges, INSERM, UMR S850, F-87025 Limoges, France

Rostaing, Lionel
论文数: 0 引用数: 0
h-index: 0
机构:
CHU Toulouse, Dept Nephrol Dialysis & Multiorgan Transplant, Toulouse, France
CHU Purpan, INSERM, U563, IFR BMT, Toulouse, France
Univ Toulouse 3, F-31062 Toulouse, France Fac Med Limoges, INSERM, UMR S850, F-87025 Limoges, France

Marquet, Pierre
论文数: 0 引用数: 0
h-index: 0
机构:
Fac Med Limoges, INSERM, UMR S850, F-87025 Limoges, France
Univ Limoges, Limoges, France
CHU Limoges, Dept Pharmacol & Toxicol, Limoges, France Fac Med Limoges, INSERM, UMR S850, F-87025 Limoges, France

Picard, Nicolas
论文数: 0 引用数: 0
h-index: 0
机构:
Fac Med Limoges, INSERM, UMR S850, F-87025 Limoges, France
Univ Limoges, Limoges, France
CHU Limoges, Dept Pharmacol & Toxicol, Limoges, France Fac Med Limoges, INSERM, UMR S850, F-87025 Limoges, France
[48]
High Frequency of Occurrence of CYP2D6 Gene Duplication/Multiduplication Indicating Ultrarapid Metabolism Among Suicide Cases
[J].
Zackrisson, A. L.
;
Lindblom, B.
;
Ahlner, J.
.
CLINICAL PHARMACOLOGY & THERAPEUTICS,
2010, 88 (03)
:354-359

Zackrisson, A. L.
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Board Forens Med, Dept Forens Genet & Forens Toxicol, Linkoping, Sweden Natl Board Forens Med, Dept Forens Genet & Forens Toxicol, Linkoping, Sweden

Lindblom, B.
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Board Forens Med, Dept Forens Genet & Forens Toxicol, Linkoping, Sweden Natl Board Forens Med, Dept Forens Genet & Forens Toxicol, Linkoping, Sweden

Ahlner, J.
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Board Forens Med, Dept Forens Genet & Forens Toxicol, Linkoping, Sweden Natl Board Forens Med, Dept Forens Genet & Forens Toxicol, Linkoping, Sweden
[49]
Effect of the P450 oxidoreductase *28 polymorphism on the pharmacokinetics of tacrolimus in Chinese healthy male volunteers
[J].
Zhang, Jing-Jing
;
Zhang, Hua
;
Ding, Xiao-Liang
;
Ma, Sheng
;
Miao, Li-Yan
.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY,
2013, 69 (04)
:807-812

Zhang, Jing-Jing
论文数: 0 引用数: 0
h-index: 0
机构:
Soochow Univ, Affiliated Hosp 1, Dept Clin Pharmacol, Res Lab, Suzhou, Peoples R China Soochow Univ, Affiliated Hosp 1, Dept Clin Pharmacol, Res Lab, Suzhou, Peoples R China

Zhang, Hua
论文数: 0 引用数: 0
h-index: 0
机构:
Soochow Univ, Affiliated Hosp 1, Dept Clin Pharmacol, Res Lab, Suzhou, Peoples R China Soochow Univ, Affiliated Hosp 1, Dept Clin Pharmacol, Res Lab, Suzhou, Peoples R China

Ding, Xiao-Liang
论文数: 0 引用数: 0
h-index: 0
机构:
Soochow Univ, Affiliated Hosp 1, Dept Clin Pharmacol, Res Lab, Suzhou, Peoples R China Soochow Univ, Affiliated Hosp 1, Dept Clin Pharmacol, Res Lab, Suzhou, Peoples R China

Ma, Sheng
论文数: 0 引用数: 0
h-index: 0
机构:
Soochow Univ, Affiliated Hosp 1, Dept Clin Pharmacol, Res Lab, Suzhou, Peoples R China Soochow Univ, Affiliated Hosp 1, Dept Clin Pharmacol, Res Lab, Suzhou, Peoples R China

Miao, Li-Yan
论文数: 0 引用数: 0
h-index: 0
机构:
Soochow Univ, Affiliated Hosp 1, Dept Clin Pharmacol, Res Lab, Suzhou, Peoples R China Soochow Univ, Affiliated Hosp 1, Dept Clin Pharmacol, Res Lab, Suzhou, Peoples R China