IL-7 receptor and VDJ recombination: Trophic versus mechanistic actions

被引：91

作者：

Candeias, S

Muegge, K

Durum, SK

机构：

[1] NCI,SAIC,FREDERICK CANC RES & DEV CTR,FREDERICK,MD 21702

[2] NCI,MOL IMMUNOREGULAT LAB,FREDERICK,MD 21702

来源：

IMMUNITY | 1997年 / 6卷 / 05期

关键词：

D O I：

10.1016/S1074-7613(00)80338-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-7 (IL-7) is required for normal lymphoid development. The rearrangement of receptor genes is induced in lymphoid progenitors during their period of IL-7 dependency. The question addressed in this review is: to what extent does IL-7 control the gene rearrangement process? There are two principal types of controls considered. The first is the 'trophic' effect: IL-7 maintains the viability of cells during gene rearrangement, whereas the signal to induce gene rearrangements may be distinct from IL-7. The second possible control is 'mechanistic': IL-7 delivers signals to induce gene rearrangement as well as maintains cell viability. This review covers current thought on how gene rearrangement is regulated and evaluates recent evidence for a mechanistic action of the IL-7 receptor in gene rearrangement.

引用

页码：501 / 508

页数：8

共 101 条

[91] BCL-2-DEFICIENT MICE DEMONSTRATE FULMINANT LYMPHOID APOPTOSIS, POLYCYSTIC KIDNEYS, AND HYPOPIGMENTED HAIR [J].