IL-7 receptor and VDJ recombination: Trophic versus mechanistic actions

被引：91

作者：

Candeias, S

Muegge, K

Durum, SK

机构：

[1] NCI,SAIC,FREDERICK CANC RES & DEV CTR,FREDERICK,MD 21702

[2] NCI,MOL IMMUNOREGULAT LAB,FREDERICK,MD 21702

来源：

IMMUNITY | 1997年 / 6卷 / 05期

关键词：

D O I：

10.1016/S1074-7613(00)80338-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-7 (IL-7) is required for normal lymphoid development. The rearrangement of receptor genes is induced in lymphoid progenitors during their period of IL-7 dependency. The question addressed in this review is: to what extent does IL-7 control the gene rearrangement process? There are two principal types of controls considered. The first is the 'trophic' effect: IL-7 maintains the viability of cells during gene rearrangement, whereas the signal to induce gene rearrangements may be distinct from IL-7. The second possible control is 'mechanistic': IL-7 delivers signals to induce gene rearrangement as well as maintains cell viability. This review covers current thought on how gene rearrangement is regulated and evaluates recent evidence for a mechanistic action of the IL-7 receptor in gene rearrangement.

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页码：501 / 508

页数：8

相关论文

共 101 条

[1]

ALVAREZ JD, 1995, J IMMUNOL, V155, P1191

[2] INTERLEUKIN-7-INDUCED EXPRESSION OF SPECIFIC T-CELL RECEPTOR-GAMMA VARIABLE REGION GENES IN MURINE FETAL LIVER CULTURES [J].

APPASAMY, PM ;

KENNISTON, TW ;

WENG, YH ;

HOLT, EC ;

KOST, J ;

CHAMBERS, WH .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (06) :2201-2206

[3] THE EFFECT OF IN-VIVO IL-7 DEPRIVATION ON T-CELL MATURATION [J].

BHATIA, SK ;

TYGRETT, LT ;

GRABSTEIN, KH ;

WALDSCHMIDT, TJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (04) :1399-1409

[4] RECOMBINATION BETWEEN IMMUNOGLOBULIN VARIABLE REGION GENE SEGMENTS IS ENHANCED BY TRANSCRIPTION [J].

BLACKWELL, TK ;

MOORE, MW ;

YANCOPOULOS, GD ;

SUH, H ;

LUTZKER, S ;

SELSING, E ;

ALT, FW .

NATURE, 1986, 324 (6097) :585-589

[5] A role for CD81 in early T cell development [J].

Boismenu, R ;

Rhein, M ;

Fischer, WH ;

Havran, WL .

SCIENCE, 1996, 271 (5246) :198-200

[6] Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: The role of enhancer elements in controlling V(D)J recombination accessibility [J].

Bories, JC ;

Demengeot, J ;

Davidson, L ;

Alt, FW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (15) :7871-7876

[7] Deletion of the mouse T-cell receptor beta gene enhancer blocks alpha beta T-cell development [J].

Bouvier, G ;

Watrin, F ;

Naspetti, M ;

Verthuy, C ;

Naquet, P ;

Ferrier, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (15) :7877-7881

[8] THE THYMIC MICROENVIRONMENT [J].

BOYD, RL ;

TUCEK, CL ;

GODFREY, DI ;

IZON, DJ ;

WILSON, TJ ;

DAVIDSON, NJ ;

BEAN, AGD ;

LADYMAN, HM ;

RITTER, MA ;

HUGO, P .

IMMUNOLOGY TODAY, 1993, 14 (09) :445-459

[9] T-CELL RECEPTOR V-BETA-8.2 GENE GERM-LINE TRANSCRIPTION - AN EARLY EVENT OF LYMPHOCYTE DIFFERENTIATION [J].

CANDEIAS, S ;

HARDY, RR ;

LI, YS ;

STAERZ, UD .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (12) :3073-3081

[10] Junctional diversity in signal joints from T cell receptor beta and delta loci via terminal deoxynucleotidyl transferase and exonucleolytic activity [J].

Candeias, S ;

Muegge, K ;

Durum, SK .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (05) :1919-1926

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