Advanced glycation end products: An emerging biomarker for adverse outcome in patients with peripheral artery disease

被引：50

作者：

de Vos, Lisanne C. ^{[1
]}

Lefrandt, Joop D. ^{[1
]}

Dullaart, Robin P. F. ^{[2
]}

Zeebregts, Clark J. ^{[3
]}

Smit, Andries J. ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Div Vasc Med, Groningen, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Div Endocrinol, Groningen, Netherlands

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Surg, Div Vasc Surg, Groningen, Netherlands

来源：

ATHEROSCLEROSIS | 2016年 / 254卷

关键词：

Advanced glycation end products; Peripheral artery disease; Biomarker; Atherosclerosis; SKIN AUTOFLUORESCENCE; RISK-FACTOR; PLASMA; PENTOSIDINE; RECEPTOR; PROTEIN; RAGE; COMPLICATIONS; ACCUMULATION; ASSOCIATION;

D O I：

10.1016/j.atherosclerosis.2016.10.012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Patients with peripheral artery disease (PAD) suffer from widespread atherosclerosis. Partly due to the growing awareness of cardiovascular disease, the incidence of PAD has increased considerably during the past decade. It is anticipated that algorithms to identify high risk patients for cardiovascular events require being updated, making use of novel biomarkers. Advanced glycation end products (AGEs) are moieties formed non-enzymatically on long-lived proteins under influence of glycemic and oxidative stress reactions. We elaborate about the formation and effects of AGEs, and the methods to measure AGEs. Several studies have been performed with AGEs in PAD. In this review, we evaluate the emerging evidence of AGEs as a clinical biomarker for patients with PAD. (C) 2016 The Authors. Published by Elsevier Ireland Ltd.

引用

页码：291 / 299

页数：9

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