Common Variable Immunodeficiency and Gastric Malignancies

被引：35

作者：

Leone, Patrizia ^{[1
]}

Vacca, Angelo ^{[1
]}

Dammacco, Franco ^{[1
]}

Racanelli, Vito ^{[1
]}

机构：

[1] Univ Bari, Dept Biomed Sci & Human Oncol, Unit Internal Med, Sch Med, I-70124 Bari, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 02期

关键词：

common variable immunodeficiency; gastric cancer; human immunoglobulins; lymphoproliferative disorders; HELICOBACTER-PYLORI INFECTION; B-CELL MATURATION; ANTIBODY DEFICIENCY; MICE LACKING; FOLLOW-UP; T-CELLS; CANCER; DISEASE; MUTATIONS; TACI;

D O I：

10.3390/ijms19020451

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Common variable immunodeficiency (CVID) is an immunodeficiency disorder with a high incidence of gastrointestinal manifestations and an increased risk of gastric carcinoma and lymphoma. This review discusses the latest advancements into the immunological, clinical and diagnostic aspects of gastric malignancies in patients with CVID. The exact molecular pathways underlying the relationships between CVID and gastric malignancies remain poorly understood. These include genetics, immune dysregulation and chronic infections by Helicobacter pylori. Further studies are needed to better stratify the risk for cancer in these patients, to elaborate surveillance programs aimed at preventing these complications, and to develop new and more effective therapeutic approaches.

引用

页数：13

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