Advances in Platelet Function Testing-Light Transmission Aggregometry and Beyond

被引：45
|
作者：
Le Blanc, Jessica [1 ,2 ]
Mullier, Francois [3 ]
Vayne, Caroline [4 ,5 ]
Lordkipanidze, Marie [1 ,2 ]
机构：
[1] Montreal Heart Inst Res Ctr, Montreal, PQ H1T 1C8, Canada
[2] Univ Montreal, Fac Pharm, Montreal, PQ H3C 3J7, Canada
[3] Catholic Univ Louvain, CHU UCL Namur, Namur Thrombosis & Hemostasis Ctr NTHC, Hematol Lab, B-5530 Yvoir, Belgium
[4] Univ Hosp Tours, Dept Hemostasis, F-37044 Tours, France
[5] Univ Tours, EA GICC 7501, F-37000 Tours, France
来源：
JOURNAL OF CLINICAL MEDICINE | 2020年 / 9卷 / 08期
关键词：
platelets; platelet functional tests; light transmission aggregometry; standardization; ADENOSINE-TRIPHOSPHATE RELEASE; FORMATION ANALYSIS SYSTEM; FLOW-CHAMBER SYSTEM; BLOOD-PLATELETS; PHYSIOLOGY SUBCOMMITTEE; AGGREGATION TESTS; BLEEDING-TIME; DIAGNOSIS; DISORDERS; ASSAYS;
D O I：
10.3390/jcm9082636
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Platelet function testing is essential for the diagnosis of hemostasis disorders. While there are many methods used to test platelet function for research purposes, standardization is often lacking, limiting their use in clinical practice. Light transmission aggregometry has been the gold standard for over 60 years, with inherent challenges of working with live dynamic cells in specialized laboratories with independent protocols. In recent years, standardization efforts have brought forward fully automated systems that could lead to more widespread use. Additionally, new technical approaches appear promising for the future of specialized hematology laboratories. This review presents developments in platelet function testing for clinical applications.
引用
收藏
页码：1 / 17
页数：18
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