IL-17 in human asthma

被引：7

作者：

Silverpil, Elin ^{[1
]}

Linden, Anders ^{[2
]}

机构：

[1] Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London EC1M 6BQ, England

[2] Univ Gothenburg, Sahlgrenska Univ Hosp, Sahlgrenska Acad,Lung Immunol Grp, Dept Internal Med Resp Med & Allergol,Div Med Onc, S-41345 Gothenburg, Sweden

来源：

EXPERT REVIEW OF RESPIRATORY MEDICINE | 2012年 / 6卷 / 02期

关键词：

anti-IL-17; therapy; asthma; glucocorticoids; hallmark pathological changes of asthma; IL-17; IL-17-targeting drug; neutrophilic asthma; steroid-resistant asthma; GLUCOCORTICOID-RECEPTOR-BETA; COLONY-STIMULATING FACTOR; GROWTH-FACTOR-BETA; CD4(+) T-CELLS; NEUTROPHIL RECRUITMENT; AIRWAY INFLAMMATION; INTERLEUKIN; 17; RHEUMATOID-ARTHRITIS; EPITHELIAL-CELLS; CUTTING EDGE;

D O I：

10.1586/ERS.12.12

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Expert Rev. Respir. Med. 6(2), 173-186 (2012) Asthma is perceived as a heterogeneous disease with several clinical phenotypes and triggering factors. In general, cytokines from T-helper 2 cells are believed to be critical contributors of asthma. In recent years, IL-17, another T-helper lymphocyte-associated cytokine, has been put forward as another potentially important mediator of asthma. Currently, several drugs that target IL-17 signaling are being tested in clinical trials. With the aim to find whether there are any specific features of this heterogeneous disease that potentially could be relieved by the use of IL-17-targeting drugs, this review scrutinizes the evidence for an involvement of IL-17 in human asthma.

引用

页码：173 / 186

页数：14

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