Fabrication and properties of L-arginine-doped PCL electrospun composite scaffolds

被引：8

作者：

Goreninskii, S. I. ^{[1
]}

Bolbasov, E. N. ^{[1
]}

Sudarev, E. A. ^{[1
]}

Stankevich, K. S. ^{[1
]}

Anissimov, Y. G. ^{[2
,3
]}

Golovkin, A. S. ^{[4
]}

Mishanin, A. I. ^{[4
]}

Viknianshchuk, A. N. ^{[5
]}

Filimonov, V. D. ^{[1
]}

Tverdokhlebov, S. I. ^{[1
]}

机构：

[1] Tomsk Polytech Univ, 30 Lenin Ave, Tomsk 634050, Russia

[2] Griffith Univ, Sch Nat Sci, Nathan, Qld, Australia

[3] Griffith Univ, Queensland Micro & Nanotechnol Ctr, Nathan, Qld, Australia

[4] Almazov Natl Med Res Ctr, St Petersburg, Russia

[5] St Petersburg Univ, St Petersburg, Russia

来源：

MATERIALS LETTERS | 2018年 / 214卷

基金：

俄罗斯科学基金会; 俄罗斯基础研究基金会;

关键词：

Biomaterials; Electrospun scaffolds; Polymeric composites; Polycaprolactone; L-arginine;

D O I：

10.1016/j.matlet.2017.11.115

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The article describes fabrication and properties of composite fibrous scaffolds obtained by electrospinning of the solution of poly(epsilon-caprolactone) and arginine in hexafluoro-2-propanol for the first time. The influence of arginine content on structure, mechanical, surface and biological properties of the scaffolds was investigated. It was found that arginine addition reduces diameter of the scaffold fibers and doesn't impair mechanical properties of the polymer. Porosity and water contact angle of the scaffold were independent from arginine content. The best adhesion and viability of multipotent mesenchymal stem cells was shown on scaffolds with arginine concentration from 0.5 to 1% wt. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：64 / 67

页数：4

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